Nicolau Syndrome After Intramuscular Steroid Injection
Case report: Nicolau syndrome after intramuscular steroid injection
Abstract: Nicolau syndrome is an uncommon side effect of intramuscular injection that results in local ischemic necrosis of the skin and adipose tissue. Pediatric cases have been less reported. In this article we present a 10 year old girl developing nicolau syndrome after intramuscular injection of steroid as a treatment for alopecia areata.
Introduction
Nicolau syndrome is a rare iatrogenic syndrome as a side effect of intramuscular injection, several medications have been implicated leading to tissue necrosis including the skin and subcutaneous tissues.[1,2] The pathogenesis is not clearly understood, Sever pain shortly or immediately after injection accompanied by purplish …show more content…
It was initially described Freudenthal and Nicolau in 1924 and 1925 following bsithmus injection for syphilis. Several medications have been implicated leading to tissue necrosis including the skin and subcutaneous tissues.[1,2] The pathogenesis is not fully understood, Sever pain shortly or immediately after injection accompanied by reticulated purplish discoloration of the overlying skin is highly characteristic. Intramuscular,[1‐10] intravenous,[13] subcutaneous,[11,12] and intra-articular[14] injections have been reported as a cause of this …show more content…
1 The necrosis often involves the muscle and is demarcated over 1–2 weeks. The eschar eventually sloughs, and the underlying ulcer heals over months, leaving an atrophic scar devoid of adnexal structures. 1,3 However, the evolution is unpredictable and the syndrome has been associated with morbid complications such as widespread cutaneous necrosis, transitory or permanent ischemia of the ipsilateral limb, various neurological complications, isolated muscular necrosis without skin lesions and superimposed
Abstract: Nicolau syndrome is an uncommon side effect of intramuscular injection that results in local ischemic necrosis of the skin and adipose tissue. Pediatric cases have been less reported. In this article we present a 10 year old girl developing nicolau syndrome after intramuscular injection of steroid as a treatment for alopecia areata.
Introduction
Nicolau syndrome is a rare iatrogenic syndrome as a side effect of intramuscular injection, several medications have been implicated leading to tissue necrosis including the skin and subcutaneous tissues.[1,2] The pathogenesis is not clearly understood, Sever pain shortly or immediately after injection accompanied by purplish …show more content…
It was initially described Freudenthal and Nicolau in 1924 and 1925 following bsithmus injection for syphilis. Several medications have been implicated leading to tissue necrosis including the skin and subcutaneous tissues.[1,2] The pathogenesis is not fully understood, Sever pain shortly or immediately after injection accompanied by reticulated purplish discoloration of the overlying skin is highly characteristic. Intramuscular,[1‐10] intravenous,[13] subcutaneous,[11,12] and intra-articular[14] injections have been reported as a cause of this …show more content…
1 The necrosis often involves the muscle and is demarcated over 1–2 weeks. The eschar eventually sloughs, and the underlying ulcer heals over months, leaving an atrophic scar devoid of adnexal structures. 1,3 However, the evolution is unpredictable and the syndrome has been associated with morbid complications such as widespread cutaneous necrosis, transitory or permanent ischemia of the ipsilateral limb, various neurological complications, isolated muscular necrosis without skin lesions and superimposed