1.1 Glioma:
Glioma is the most common primary brain tumor [1, 2] and it is one of the most rapidly growing, therapy resistant and devastating cancers [3]. High-grade glioma patient’s prognosis is very poor [4, 5] and the median survival is only 14.6 months after receiving all the currently available treatments [1]. A new effective therapeutic approach is urgently needed to give some hope to the glioma patients.