Pdf of Stem Cell
STEM CELLS®
TISSUE-SPECIFIC STEM CELLS
Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells
Julianne N. P. Smith and Laura M. Calvi
Key words. Adult haematopoietic stem cells Bone marrow Bone marrow stromal cells Hematopoiesis Hemopoietic stem cells Osteoblast Stem cellmicroenvironment interactions Endothelial cell
ABSTRACT
“Within the microanatomy of mammalian bone, hematopoietic stem and progenitor cells (HSPCs) interact with numerous cell types and molecules. Throughout development as well as in adulthood, the local microenvironment of HSPCs plays an instructive role in stem cell fate. Here we will discuss recent reports on these regulatory interactions. While a comprehensive report on all the cellular components of the HSC niche is beyond the scope of this concise review, we have specifically chosen to highlight topics with therapeutic relevance, where clinical translation can be envisioned within the near future. A comprehensive summary of cellular components of the niche identified so far is included.
INTRODUCTION Within the microanatomy of mammalian bone, hematopoietic stem and progenitor cells (HSPCs) interact with numerous cell types and molecules. Throughout development as well as in adulthood, the local microenvironment of HSPCs plays an instructive role in stem cell fate. Here we will discuss recent reports on these regulatory interactions. While a comprehensive report on all the cellular components of the HSC niche is beyond the scope of this concise review, we have specifically chosen to highlight topics with therapeutic relevance, where clinical translation can be envisioned within the near future. A comprehensive summary of cellular components of the niche identified so far is included (TABLE).
Anatomical Location of HSCs in Mammals Hematopoietic stem cells (HSC) originate developmentally from the dorsal aortic endothelium of the aorta-gonad-mesonephros (AGM) region (reviewed in
TISSUE-SPECIFIC STEM CELLS
Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells
Julianne N. P. Smith and Laura M. Calvi
Key words. Adult haematopoietic stem cells Bone marrow Bone marrow stromal cells Hematopoiesis Hemopoietic stem cells Osteoblast Stem cellmicroenvironment interactions Endothelial cell
ABSTRACT
“Within the microanatomy of mammalian bone, hematopoietic stem and progenitor cells (HSPCs) interact with numerous cell types and molecules. Throughout development as well as in adulthood, the local microenvironment of HSPCs plays an instructive role in stem cell fate. Here we will discuss recent reports on these regulatory interactions. While a comprehensive report on all the cellular components of the HSC niche is beyond the scope of this concise review, we have specifically chosen to highlight topics with therapeutic relevance, where clinical translation can be envisioned within the near future. A comprehensive summary of cellular components of the niche identified so far is included.
INTRODUCTION Within the microanatomy of mammalian bone, hematopoietic stem and progenitor cells (HSPCs) interact with numerous cell types and molecules. Throughout development as well as in adulthood, the local microenvironment of HSPCs plays an instructive role in stem cell fate. Here we will discuss recent reports on these regulatory interactions. While a comprehensive report on all the cellular components of the HSC niche is beyond the scope of this concise review, we have specifically chosen to highlight topics with therapeutic relevance, where clinical translation can be envisioned within the near future. A comprehensive summary of cellular components of the niche identified so far is included (TABLE).
Anatomical Location of HSCs in Mammals Hematopoietic stem cells (HSC) originate developmentally from the dorsal aortic endothelium of the aorta-gonad-mesonephros (AGM) region (reviewed in