Pharm
TITLE PAGE
PREPARATION AND CHARACTERIZATION OF SODIUM SALICYLATE OINTMENT INTENDED FOR TOPICAL AND SYSTEMIC DELIVERY
BY
MUOBIKE MAKUO
2005/136609
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF DEGREE OF BACHELOR OF PHARMACY (B. PHARM) OF THE UNIVERSITY OF NIGERIA, NSUKKA.
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
FACULTY OF PHARMACEUTICAL SCIENCES
UNIVERSITY OF NIGERIA, NSUKKA.
PROJECT SUPERVISOR: DR. I. V. ONYISHI
OCTOBER, 2012.
APPROVAL PAGE
This is to certify this project was carried out by Muobike Makuo and submitted to the Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
DR. I. V. ONYISHI
Project Supervisor Head of Department
Date:…………………………... Date:……………………
………………………………………….
External Examiner
DEDICATION
In loving memory of my Mum, lady S.N. Muobike. My dad Sir Engr. Muobike, I love you infinitely.
My Family, bound by a lot more than blood.
ACKNOWLEDGEMENT
To God almighty, strenghting my weakness, I owe everything.
Hearfelt gratitude to my supervisor and professional role-model Dr. I.V.
Onyishi, for his patience in my depth of distractions, God bless and keep you Sir.
Special thanks to Dr. Omeje, for his genuine academic and life counsel.
Thanks To all the staff of Pharmaceutical Technology for their support and kind words.
To my siblings, Nnenne and ari-boy and our entire family, may we all grow from strength to strength.
Nkechi and Ndidi my adopted sisters, I love you plenty.
Okegbe Kelvin and Egwatu Victor, my bossom friends and patners, thanks for sticking around….
ABSTRACT
The project developed sodium salicylate ointment with a view to achieving both topical and systemic release through co-solvency preparation technique. The effects of two ointment bases: shea butter and petrolatum in the presence of propylene glycol, and menthol in the release of sodium salicylate was studied. Release studies of
PREPARATION AND CHARACTERIZATION OF SODIUM SALICYLATE OINTMENT INTENDED FOR TOPICAL AND SYSTEMIC DELIVERY
BY
MUOBIKE MAKUO
2005/136609
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF DEGREE OF BACHELOR OF PHARMACY (B. PHARM) OF THE UNIVERSITY OF NIGERIA, NSUKKA.
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
FACULTY OF PHARMACEUTICAL SCIENCES
UNIVERSITY OF NIGERIA, NSUKKA.
PROJECT SUPERVISOR: DR. I. V. ONYISHI
OCTOBER, 2012.
APPROVAL PAGE
This is to certify this project was carried out by Muobike Makuo and submitted to the Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
DR. I. V. ONYISHI
Project Supervisor Head of Department
Date:…………………………... Date:……………………
………………………………………….
External Examiner
DEDICATION
In loving memory of my Mum, lady S.N. Muobike. My dad Sir Engr. Muobike, I love you infinitely.
My Family, bound by a lot more than blood.
ACKNOWLEDGEMENT
To God almighty, strenghting my weakness, I owe everything.
Hearfelt gratitude to my supervisor and professional role-model Dr. I.V.
Onyishi, for his patience in my depth of distractions, God bless and keep you Sir.
Special thanks to Dr. Omeje, for his genuine academic and life counsel.
Thanks To all the staff of Pharmaceutical Technology for their support and kind words.
To my siblings, Nnenne and ari-boy and our entire family, may we all grow from strength to strength.
Nkechi and Ndidi my adopted sisters, I love you plenty.
Okegbe Kelvin and Egwatu Victor, my bossom friends and patners, thanks for sticking around….
ABSTRACT
The project developed sodium salicylate ointment with a view to achieving both topical and systemic release through co-solvency preparation technique. The effects of two ointment bases: shea butter and petrolatum in the presence of propylene glycol, and menthol in the release of sodium salicylate was studied. Release studies of
References: Handbook of Pharmaceutical Excipients. 3rd edition ed. A.H. Kebbe, Pharmaceutical Press, London, UK, 2000 pp 334-335.