Pharmaceuticals Ert

Pharmaceuticals ERT

Pharmaceuticals- Extended Response Task

Table of Contents

1.0 ABSTRACT 3
2.0 INTRODUCTION 3
2.1 The background information of Aspirin 3
2.11 History 3
2.12 chemical structures 4
2.2 The background information of Acetaminophen 5
2.21 History 5
2.22 Chemical Structures 6
3.0 BODY 6
3.1 Synthesis 6
3.11 Synthesis of Aspirin 6
3.12 Synthesis of Acetaminophen 7
3.2 Mechanism of Action in Human Body 9
3.2.1 Pain as a warning system 9
3.2.2 Aspirin 9
3.2.3 Acetaminophen 10
3.3 Side effects 10
3.3.1 Side effects of Aspirin 10
3.3.2 Side effects of Acetaminophen 11
4.0 EVALUATION AND RECOMMENDATIONS 12
5.0 CONCLUSION 13
6.0 BIBLIOGRAPHY 14
BOOKS/ REPORTS: 14
WEBSITE: 14
7.0 APPENDICES 17
Appendices 1 17 17
Appendices 2 17 17
Appendices 3 18

1.0 ABSTRACT

Pharmacology is the study of how the natural and synthetic chemical agents affect biological systems (Antonio, 2008). Both the Aspirin and Acetaminophen, a suitable alternative to Aspirin, are used to reduce substances in the body that cause pain, fever and inflammation (acetaminophen, aspirin, and caffeine, 2011). However, Acetaminophen could be used as alternative drug for patients allergic to aspirin (acetaminophen, aspirin, and caffeine, 2011). Through an analysis and evaluation of the comparison between aspirin and Acetaminophen, it was conclusive that the Acetaminophen is more effective than aspirin. Firstly, Acetaminophen is fixing the damage that initially triggers the pain, but Aspirin does not. Secondly, it works as a selective COX-2 inhibitor to make it does not restrain the pain and it is much safer for children. Finally, it has fewer side effects than Aspirin, such as stomach irritation.
2.0 INTRODUCTION
2.1 The background information of Aspirin
Aspirin was one of the first drugs to become commonly used and is the most widely used over-the-counter drug in the world. The formula of Aspirin is C9H8O4.It falls within the category of

Bibliography:  shanbhag. (2006). Synthesis of Acetaminophen WEBSITE:  Fascinating facts about the invention of Aspirin by Felix Hoffmann in 1897. (2006, March 3). Retrieved March 8, 2012, from THE GREAT IDEA FINDER: http://www.ideafinder.com/history/inventions/aspirin.htm  Acetaminophen  Acetaminophen. (2008, April 27). Retrieved April 20, 2012, from NEW WORLD ENCYCLOPEDIA: http://www.newworldencyclopedia.org/entry/Acetaminophen  What is the pharmacophore of paracetamol  acetaminophen, aspirin, and caffeine. (2011, August 23). Retrieved March 30, 2012, from Drugs.com: http://www.ehow.com/about_4564995_acetaminophen-vs-aspirin.html  Paracetamol Tablets  What is the drug Paracetamol? (2011). Retrieved April 23, 2012, from innovateus: http://www.innovateus.net/health/what-drug-paracetamol  Acetaminophen systemaic name  Aspirin or Acetylsalicylic Acid. (2012). Retrieved April 30, 2012, from About.com.Chemistry: http://chemistry.about.com/od/medicalhealth/ig/Drug-Photo-Gallery/Aspirin.-1VJ.htm  The Chemistry of Aspinrin  The History of Aspirin. (2012). Retrieved March 9, 2012, from BAYER ASPIRIN: http://www.wonderdrug.com/pain/asp_history.htm  Antonio, S  AssistPainRelief. (2005). AssistPainRelief. Retrieved March 17, 2010, from Aspirin: http://www.assistpainrelief.com/dyn/298/Aspirin.html  Bellis, M  genomequest,INC. (2006, Oct 5). DrugBank. Retrieved Mar. 23, 2010, from Showing drug card for Acetylsalicylic acid (DB00945): http://www.drugbank.ca/drugs/DB00945  Graham GG, S  Harrington, M. (2006, August 9). A short guide to aspirin. Retrieved March 2010, 29, from Aspirin: http://www.biology.ualberta.ca/people/mike_harrington/biol107/aspirin/aspirin.htm  Henderson, G  Hinz B, C. O. (2007). Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. PubMed.  Kalgutkar, e. a. (1998). Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2.  Knight, K. (2010). Chemistry Explained. Retrieved March 24, 2010 , from Acetaminophen : http://www.chemistryexplained.com/A-Ar/Acetaminophen.html  Kristi Monson, P  Lagrimas, M. (2012). Basic Facts about Acetaminophen. Retrieved April 26, 2012, from Hubpages: http://melody-lagrimas.hubpages.com/hub/Basic-Facts-about-Acetaminophen  Lloyd, J  Lycos Inc. (2009). Multimania. Retrieved April 7, 2010, from Aspirin 's Structure & Functional Groups: http://members.multimania.co.uk/arbee222/structure.html  Orsini, M  Pérez, M. (2009, Octomber 9). Maritza Pérez Blog. Retrieved April 5, 2010, from Second post: http://maritzaperez6270.wordpress.com/2009/10/09/second-post/  Ross-Flanigan, N., & Uretsky, S  shanbhag. (2006). Synthesis of Acetaminophen. 7.0 APPENDICES