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phthalates
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Phthalates, Environmental Pollutants

Today, there is a great concern on chemical substances that accumulate in the environment which become pollutants in high concentrations that can cause serious threats and hazards in the environment and in the organisms living in it by imitating hormones and changing the normal functions of the endocrine system and by carrying diseases in humans and other organisms. These compounds can be naturally occurring in the environment but most of them are by-products of human activities like in chemical industries or companies. Phthalates are one of these chemical compounds that are found abundantly in the environment.
Phthalates belong to a family of chemical compounds or substances which are based on a benzene ring (a six carbon membered compound), to which is attached a pair of carbonyl groups in consecutive positions on the benzene ring (Sheeba et. al.). They are a family of industrial compounds with a common chemical structure, dialkylor alkyl arylestersof1, 2-benzenedicarboxylicacid. They are usually clear liquids when they are found in nature, most of them are odorless, some with faint sweet odors and some with faint yellow color. Phthalates are known to be one of the most abundant chemical compounds that act as pollutants in the world and they are commonly found in the environment or in nature where most humans and other living systems are exposed at low levels in air, water, and food specifically di-(2-ethylhexyl) phthalate (DEHP), which is the most commonly used as plasticizers. It was reported that 18 billion pounds of phthalates are produced and used annually and 2M tons of DEHP are produced each year worldwide (Lorz, et. al.).
They are widely used as additives in plastic manufacturing to improve mechanical properties of plastic resin, particularly flexibility. They are however not covalently bounded to the resins; thus, phthalates are able to migrate and



Cited: ACGIH. 1991. American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices, 6th ed. ACGIH, Cincinnati, OH, pp. 1263-1265. Agency for Toxic Substances and Disease Registry (ATSDR). 2001. Toxicological Profile for Di-n-Butyl Phthalate. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. Akingbemi, B.T., R. Ge, G.R. Klinefelter, B.R. Zirkin and M.P. Hardy. 2003. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. PNAS 101(3):775-78. Christiansen, L.B., K.L. Pedersen, B. Korsgaard, and P. Bjerregaard. 1998. Estrogenicity of xenobiotics in rainbow trout (Oncorhynchusmykiss) using in vivo synthesis of vitellogenin as a biomarker. Mar. Environ. Res. 46(1-5): 137-140. European Commission. 1996. European workshop on the impact of endocrine disrupters on human health and wildlife. Report EUR 17549, Environment and Climate Research Program, European Commission. Gillesby, B.E., and T.R. Zacharewski. 1998. Exoestrogens: mechanisms of action and strategies for identification and assessment Gkorgkolia, C., E. Bizani, and K. Fytianos. 2009. PHOTO-FENTON DECOMPOSITION OF ENDOCRINE DISRUPTING COMPOUND DI-BUTYL PHTHALATE. Thessaloniki, Greece: Environmental Pollution Control Laboratory, Chemistry Department Aristotle University of Thessaloniki. Harris, C. A., P. Henttu, M. G. Parker, and J. P. Sumpter. 1997. The estrogenic activity of phthalate esters in vitro. Environ.HealthPerspect. 105(8): 802-811. Lee, J. 2009. Child Obesity is Linked in Chemicals in Plastics. New York Times. Lorz, P.M.,F.K. Towae,W. Enke, R. Jackh and N. Bhargava. 2002. Phthalic acid and derivatives. Ullmann’s Encyclopedia of Industrial Chemistry.Weinheim7: Wiley-VCH Harris, C.A., P esters In vitro. Environ. Health Perspect., 105: 802-810. IUPAC Compendium of Chemical Terminology, 2005 Jobling, S., M. Nolan, C.R. Tyler, G. Brightly, and J.P. Sumpter. 1998. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 32:2498-2506. Ohtani, H., I. Miura and Y. Ichikawa. 2000. Effects of Dibutyl Phthalate as an Environmental Endocrine Disruptor on Gonadal Sex Differentiation of Genetic Males of the Frog Ranarugosa. Environ. Health Perspect. 108 (12): 1189-1193. Pait, A.S. and J. O. Nelson. 2002. Endocrine Disruption in Fish: An Assessment of Recent Research and Results. NOAA Tech. Memo. NOS NCCOS CCMA 149. Silver Spring, MD: NOAA, NOS, Center for Coastal Monitoring and Assessment 55pp. Philippine Online Chronicles. 2010. The ‘outlawing’ of plastic in Los Banos, Laguna.http://www.thepoc.net/thepoc-features/buhay-pinoy/buhay-pinoy-features/9045-los-banos-a-plastic-less-community.html. . Quan, C.S., Q. Liu., W. J. Tian, J. Kikuchi and S.D. Fan. 2004. Biodegradation of an endocrine-disrupting chemical, di-2-ethyl phthalate, by Bacillus subtilisNo.66. Applied Microbiology and Biotechnology. Heidelberg: Springer Berlin. pp. 702-710. Sheeba, M., F. Hasan, A.A Shah, A. Hameed and S. Ahmed. 2007. Isolation of Phthalic acid degrading Pseudomonas sp. P1 from Soil. Pak. J. Bot., 39(5): 1833-1841 Soto, A.M., C Tanaka, T., K. Yamada, T. Iijima, T. Iriguchi and Y, Kido. 2006. Complete Degradation of Endocrine-Disrupting Chemical Phthalic Acid by Flavobacterium sp. Journal of Health Science.52(6): 800-804. The Medical News. 2010. Phthalate exposure can affect child’s neurobehavioral development, says study. http://www.news-medical.net/news/20100128/Phthalate-exposure-can-affect-child’s-neurobehavioral-development-says-study.aspx. U.S

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