Picornavirus

Picornavirus belongs to the virus family Picornaviridae. Natural hosts include human. It's implicated in wide verities of diseases including paralysis, summer cold, meningitis, diarrhea, foot-and-mouth disease, myocarditis, common cold, and hepatitis. Picornaviruses contain positive-sense, single-stranded RNA genomes and replicate in the cytoplasm of infected cells. The virus disrupts the nucleocytoplasmic trafficking of cells to promote viral replication. Cellular host proteins are required for both translation and RNA replication As a result of the limited coding capacity of the virus. Furthermore, picornavirus proteins can limit host cell transcription and down-regulate host antiviral responses after entering the nucleus of infected cells