Preparation of aspirin and oil of wintergreen
preparation of aspirin and oil of wintergreen |
Introduction
Organic compounds are those which contain carbon as well as a select other elements. An organic acid however, is an organic compound which contains acidic properties. An ester is an example of being a derivative of these organic acids. Esters can be prepared by the reaction of carboxylic acids and alcohols, with an inorganic acid used as a catalyst which is dubbed esterification. With o-hydrobenzoic acid, or salicylic acid, we are able to create acetylsalicylic acid otherwise known as aspirin as well as methyl salicylate, which is a component of oil of wintergreen. Both of which are used for pain relief/soreness.
Salicylic acid is a member of the phenol class as their hydroxyl group (OH) is attached to a phenyl ring (benzene) and many phenols react with ferric chloride to cause a colour change. And so, in this investigation we are to prepare the two esters and compare their reactions with ferric chloride compared to the reaction between salicylic acid and the ferric chloride in order to identify phenolic properties.
Materials
Lab Equipment
125 ml Erlenmeyer flask
10 ml Graduated cylinder
Small watch glass
Thermometer
Filter paper
600 ml Beaker
Large test tubes
Hot plate
Funnel
Chemicals
Acetic anhydride
1% Ferric Chloride Solution
Salicylic Acid
Ice
Ethanol
Methyl Alcohol
Concentrated Sulfuric Acid
Distilled Water
Procedure
Synthesis of Aspirin
1. Place 3 grams of Salicylic acid in a Erlenmeyer flask and record the mass
2. Add 6 ml of Acetic anhydride to the flask of salicylic acid
3. Add 5 drops of concentrated sulfuric acid to the flask of salicylic acid
4. Swirl the flask in order to mix the reagents
5. Heat a beaker of water on the hot plate to 80-90 degrees Celsius, use the thermometer to check temperature
6. Place the flask of reagents into the beaker of heated water for 20 minutes
7. Remove the flask after 20
Introduction
Organic compounds are those which contain carbon as well as a select other elements. An organic acid however, is an organic compound which contains acidic properties. An ester is an example of being a derivative of these organic acids. Esters can be prepared by the reaction of carboxylic acids and alcohols, with an inorganic acid used as a catalyst which is dubbed esterification. With o-hydrobenzoic acid, or salicylic acid, we are able to create acetylsalicylic acid otherwise known as aspirin as well as methyl salicylate, which is a component of oil of wintergreen. Both of which are used for pain relief/soreness.
Salicylic acid is a member of the phenol class as their hydroxyl group (OH) is attached to a phenyl ring (benzene) and many phenols react with ferric chloride to cause a colour change. And so, in this investigation we are to prepare the two esters and compare their reactions with ferric chloride compared to the reaction between salicylic acid and the ferric chloride in order to identify phenolic properties.
Materials
Lab Equipment
125 ml Erlenmeyer flask
10 ml Graduated cylinder
Small watch glass
Thermometer
Filter paper
600 ml Beaker
Large test tubes
Hot plate
Funnel
Chemicals
Acetic anhydride
1% Ferric Chloride Solution
Salicylic Acid
Ice
Ethanol
Methyl Alcohol
Concentrated Sulfuric Acid
Distilled Water
Procedure
Synthesis of Aspirin
1. Place 3 grams of Salicylic acid in a Erlenmeyer flask and record the mass
2. Add 6 ml of Acetic anhydride to the flask of salicylic acid
3. Add 5 drops of concentrated sulfuric acid to the flask of salicylic acid
4. Swirl the flask in order to mix the reagents
5. Heat a beaker of water on the hot plate to 80-90 degrees Celsius, use the thermometer to check temperature
6. Place the flask of reagents into the beaker of heated water for 20 minutes
7. Remove the flask after 20