Proteinopathy
What does the suffix -opathy mean? What is a proteinopathy? The suffix -othapy denotes a disease or disorder. A proteinopathy is any disease caused by a malformed protein.
2. Where are tau proteins found? What do they do here? Tau proteins are found inside of nerve cells. Tau proteins perform the function of stabilizing microtubules.
3. What is an isoform? How many tau isoforms are there in the brain? An isoform is a protein that has the same function as another protein but is encoded by a different gene and may have small differences in its sequence. There are 6 tau isoforms in the brain.
4a. What is phosphorylation?
Phosphorylation is the addition of a phosphate group to a protein or other organic molecule.
4b. What enzyme causes phosphorylation?
Kinases enzymes such as serine/threonine kinase cause phosphorylation.
4c. What is …show more content…
Who is this disease often found in? This disease is often found in former players of contact sports such as football, soccer, ice hockey, lacrosse, or boxing. It’s also found often in people with histories of car crashes, exposure to explosions during combat, or head injuries during seizures.
9. Compare the spread of tau proteins in Alzheimer’s patients and CTE patients. CTE’s tau protein tangles appear first in regions of the brain that aren’t typically affected by Alzheimer’s disease. In CTE, tau is primarily found in the surface regions of the cortex. The brain of a person with CTE would have valleys with the highest levels of tau. Whereas in the Alzheimer’s, the protein is found deeper within the brain, and is much more evenly spread throughout.
10. Summarize tau, its normal role in the brain, and how it can cause diseases. Tau is a protein abundant in nerve cells that perform the function of stabilizing microtubules. They achieve control of microtubule stability in phosphorylation. Hyperphosphorylation can cause the filaments to tangle. These neurofibrillary tangles contribute to the pathology of Alzheimer’s
2. Where are tau proteins found? What do they do here? Tau proteins are found inside of nerve cells. Tau proteins perform the function of stabilizing microtubules.
3. What is an isoform? How many tau isoforms are there in the brain? An isoform is a protein that has the same function as another protein but is encoded by a different gene and may have small differences in its sequence. There are 6 tau isoforms in the brain.
4a. What is phosphorylation?
Phosphorylation is the addition of a phosphate group to a protein or other organic molecule.
4b. What enzyme causes phosphorylation?
Kinases enzymes such as serine/threonine kinase cause phosphorylation.
4c. What is …show more content…
Who is this disease often found in? This disease is often found in former players of contact sports such as football, soccer, ice hockey, lacrosse, or boxing. It’s also found often in people with histories of car crashes, exposure to explosions during combat, or head injuries during seizures.
9. Compare the spread of tau proteins in Alzheimer’s patients and CTE patients. CTE’s tau protein tangles appear first in regions of the brain that aren’t typically affected by Alzheimer’s disease. In CTE, tau is primarily found in the surface regions of the cortex. The brain of a person with CTE would have valleys with the highest levels of tau. Whereas in the Alzheimer’s, the protein is found deeper within the brain, and is much more evenly spread throughout.
10. Summarize tau, its normal role in the brain, and how it can cause diseases. Tau is a protein abundant in nerve cells that perform the function of stabilizing microtubules. They achieve control of microtubule stability in phosphorylation. Hyperphosphorylation can cause the filaments to tangle. These neurofibrillary tangles contribute to the pathology of Alzheimer’s