Psychoactive substances apply their effects by transforming biochemical or physiological processes in the brain. The message system of nerve cells, or neurons, relies on both electrical and chemical transmission. Neurons rarely touch each other; there is a microscopic gap between one neuron and the next, called the synapse. When a neuron fires, it releases chemicals called neurotransmitters into the synapse. Psychoactive drugs act by altering neurotransmitter function, they bind to the site of the firing neuron and inhibit this process so the neurotransmitters remain in the synapse, where they extend and increase the normal effect. The drugs can be separated into six key pharmacological classes based on their desired behavioral or psychological effect: alcohol, sedative-hypnotics, hallucinogens, narcotic analgesics, stimulant-euphoriants, and psychotropic drugs.
The most used psychoactive substance is alcohol, which is also the only psychoactive drug legally available without a prescription in most countries. Enjoyable relaxation is often the ideal effect from alcohol consumption, but intoxication weakens judgment and motor performance, as well as brings on a feeling of exhilaration, and exaltation followed by sleep. Alcohol is a stimulant at first but after more is consumed it becomes a depressant. Alcohol is addictive. Continual use of alcohol can lead to disease known as alcoholism. Alcoholism can be classified as a chronic illness, psycho, somatic, or psychosomatic. It manifests itself as disorder of behavior. When consumed continually, alcohol consumption can be extremely harmful to the liver and brain cells, as well as physiologically addicting, generating hazardous withdrawal symptoms. It is possible to overdose from alcohol. Alcohol increases danger when taken