It is usually benign; Pheochromocytoma is a well-encapsulated, lobular, vascular tumor that can weigh less than 70 g, to 3600 g. It is made up of chromaffin tissue of the adrenal medulla or sympathetic par ganglia. The most apparent symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Attacks may occur every few months or several times daily and typically last less than five minutes. Physical and emotional stresses can initiate an attack.
As cancer is rare among cases of pheochromocytoma, the research about the best treatments is still relatively limited. Treatments for malignant tumors and metastasized cancer related to a pheochromocytoma may include the following:
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These medications inhibit the function of naturally occurring molecules that promote the growth and spread of cancerous cells.
Serotonin syndrome
It is a potentially serious drug interaction. It occurs when too much serotonin builds up in your body. Nerve cells normally produce serotonin. It’s a neurotransmitter, which is a chemical. It helps regulate:
• digestion
• blood flow
• body temperature
• breathing
It also plays an important role in the proper functioning of nerve and brain cells.
Antidepressants associated with serotonin syndrome include:
• selective serotonin reuptake inhibitors (SSRIs), such as Celexa and Zoloft
• serotonin and norepinephrine reuptake inhibitors (SNRIs), such as Effexor
• tricyclic antidepressants, such as nortriptyline and amitriptyline
• monoamine oxidase inhibitors (MAOIs), such as Nardil and Marplan
• other antidepressants, such as Wellbutrin (also used to control tobacco addiction)
Migraine medications in a drug category called “triptans” are also associated with serotonin syndrome. These include:
• Axert
• Amerge
• Imitrex
Certain illegal drugs are associated with serotonin syndrome. These include:
• LSD
• ecstasy (MDMA)
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