SEROLOGY OUTLINE OF TOPICS

OUTLINE OF TOPICS
IMMUNOLOGY AND SEROLOGY

Dec 14, 2014
8:00 am – 12:00 nn

Part 1: IMMUNOLOGY
UNIT 1: INTRODUCTION
1. Historical Development
2. Definition of Terms

UNIT II: IMMUNITY
1. Natural/Innate Immunity
First line of Defense
Anatomical/ Physical Barriers of Infections
Second Line of Defense
Physiological Barriers
Biochemical Factors
Cellular Factors
Phagocytosis
Third Line of Defense
Immune response
2. Acquired/Adaptive Immunity
Active Acquired Immunity
Passive Acquired Immunity
Humoral Immunity
Cell-Mediated Immunity
Cytokines

Dec 15, 2014
8:00 am – 12:00 nn

UNIT III: THE IMMUNE SYSTEM
1. Phylogeny of the Immune System
2. Anatomy Compartments of the Immune System
3. Anatomy and Physiology of the Lymphoid Organs
4. Cells of the Immune System
Ontogeny of the Lymphoid Cells
Characteristics and Functions of the Lymphoid
Cells and other cells involved in the Immune Response

Dec 16, 2014
8:00 am – 1:30 pm

UNIT IV. ANTIGENS
1. Structure and Biologic Properties of an Antigen
2. Factors Affecting Immunogenicity

UNIT V. ANTIBODIES
1. Biologic Structure and Functional Properties of Antibodies
2. Classification of Antibodies
3. Enzymatic Fragmentation and Reduction of An Antibody Molecule
4. Theories of Antibody Synthesis
5. Immunoglobulin Genetics
6. Antibody Diversity
7. Monoclonal Antibody Production

Dec 22, 2014 PRELIM EXAM

Jan 18, 2015
8:00 am – 12:00 nn

UNIT VI. MAJOR HISTOCOMPATIBILITY COMPLEX
1. MHC Cluster of Genes: Characteristics and Importance
2. MHC Genetic Regions
1. H2 Complex Map
2. HLA Complex Map
3. HLA Classes of Molecules
4. HLA Testing and Their Application

UNIT VII: COMPLEMENT SYSTEM
1. Major Proteins of the Complement System
2. Pathways of Activation
3. Biologic Consequences of Activation
4. Measurement of its Biologically Active Components

UNIT VIII: BIOLOGY OF THE IMMUNE RESPONSE
1. Fate of the Antigen
2. Phases of Immune response
3. Structure and Functions of the T cell Receptor (TCR)
4. T and B cell Activation Process

Jan 19,