When Dominic "Dom" Toretto (Vin Diesel) is being transported to Lompoc prison by bus, his sister Mia Toretto (Jordana Brewster) and friend Brian O'Conner (Paul Walker) lead an assault on the bus, causing it to crash, freeing Dom. While authorities search for them, the trio escape to Rio de Janeiro. Awaiting Dom's arrival, Mia and Brian join their friend Vince (Matt Schulze) and other participants on a job to steal three cars from a train. While aboard the train, Brian and Mia discover the train is carrying DEA agents and that the cars are seized property. When Dom arrives with the rest of the participants, he realizes that one of them, Zizi (Michael Irby), is only interested in stealing one car – a Ford GT40. Dom has Mia steal the car herself while Dom and Brian fight Zizi and his henchmen, with Zizi killing the DEA agents assigned to the vehicles. Dom and Brian are captured and brought to crime lord – and owner of the cars – Hernan Reyes (Joaquim de Almeida), Zizi's boss where he orders the pair be interrogated to discover the location of the car. However they manage to escape and retreat to their safehouse.
While Brian, Dom, and Mia examine the car to discover its importance, Vince arrives and is caught trying to remove a computer chip from the car, admitting that he was planning to sell it to Reyes on his own. Dom forces Vince to leave and after investigating the chip, Brian discovers it contains details of Reyes' criminal empire including the locations of $100 million in cash. Following the murder of the DEA agents aboard the train, blamed on Dom and his team, U.S. Diplomatic Security Service (DSS) agent Luke Hobbs (Dwayne Johnson) and his team arrive in Rio to capture Dom and Brian. They travel to Dom's safehouse with assistance from local officerElena Neves (Elsa Pataky), but find it under assault by Reyes' men. Brian, Dom and Mia escape with Dom suggesting they split up and leave Rio, but Mia announces she is pregnant with