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Structural Insertions In Chromosomes

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As explained on the previous page structural variations in the genome has many effects and there are many different types of structural variations. Copy number variations is a big category of different structural variation types,such as Insertions and deletions, which are genomic imbalances. There are also inversions and translocations.These structural variations are the cause of a vast range of genetic disorders. Insertions are the addition of a sequence of one or more nucleotides between two adjacent nucleotides. They range in size from small, one base pair to large, a section of a chromosome.When a section of a chromosome is entered into another chromosome insertions can occur due to unequal crossover in meiosis. There are two types of insertions, an P nucleotide insertion and a N region addition. An insertion in an F8 gene can cause haemophilia A.Haemophilia is an x linked bleeding disorder in humans that is caused by muatations in the F8 gene. Deletions too cause a mutuation which result in this disease. …show more content…

It occurs when a sequence of DNA is lost during DNA replication. Similar to insertions it can be small or a large. A single base can be lost or a full chromosome. This can occur because of mishaps of crossing over in meosis.Deletions are cause of some serious genetic diseases. There are three types of deletions.a microdeletion is a small deletion. Interstitial deletions occur in the interior of a chromosome. Terminal deletions occur at the end of a chromosome. Smaller deletions are not as dangerous as larger ones. Microdeletions are more common in children causing physical abnormalities. An example of a terminal deletion is the removal of the short arm of chromosome 5. This causes a disese called chri du chat syndrome. This syndrome occurs in newborns and has many symptoms such as a high pitched cry, slow growth, small

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