Student
International Journal of Pharma and Bio Sciences
RESEARCH ARTICLE ARTICALTICLE MEDICINAL CHEMISTRY
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SCHIFF BASES METAL COMPLEXES CO (II), ZN (II), NI (II), AND MN (II) DERIVED FROM AMOXICILLIN TRIHYDRATE WITH VARIOUS ALDEHYDES.
Corresponding Author
SUNIL JOSHI
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).
Co Authors
VATSALA PAWAR , AND V.UMA
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).
ABSTRACT
In the present investigation some new Schiff bases derived from Amoxicillin trihydrate with Cinnamaldehyde and p-Chlorobenzaldehyde and their complexes with bivalent transition metal ions viz. Co(II), Zn(II), Ni(II), and Mn(II), have been synthesized. The ligand and their metal complexes were characterized on the basis of elemental analysis and micro analytical datas. Shift in the characteristic spectral frequency of the metal complexes, confirms the coordination through metal ion with azomethine group. They were screened for antibacterial activity against several bacterial strains namely E. coli(-), S. aureus(+) M. luteus(+) and B. lichenformis(+) (ATCC), the metal complexes showed enhanced antibacterial activity compared to uncomplexed ligand.
This article can be downloaded from www.ijpbs.net P - 240
KEY WORD
Antibacterial activity, Amoxicillin trihydrate.
INTRODUCTION
Compound containing imines bases have not only found extensive application in organic synthesis,1-2 but several of these molecules display significant biological activity. In the last decade Schiff base ligands 3-6 have received more attention mainly because of their wide application in the field of catalysis and due to their antimicrobia, 11-12 anti-tuberculosis7 and anti-tumor activity. They easily form stable complexes with most transition metal ion.13-14 The development of the field of
RESEARCH ARTICLE ARTICALTICLE MEDICINAL CHEMISTRY
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SCHIFF BASES METAL COMPLEXES CO (II), ZN (II), NI (II), AND MN (II) DERIVED FROM AMOXICILLIN TRIHYDRATE WITH VARIOUS ALDEHYDES.
Corresponding Author
SUNIL JOSHI
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).
Co Authors
VATSALA PAWAR , AND V.UMA
Synthetic Lab, P. G. Department of Chemistry, Faculty of Science, Government College, Ajmer, Rajasthan (INDIA).
ABSTRACT
In the present investigation some new Schiff bases derived from Amoxicillin trihydrate with Cinnamaldehyde and p-Chlorobenzaldehyde and their complexes with bivalent transition metal ions viz. Co(II), Zn(II), Ni(II), and Mn(II), have been synthesized. The ligand and their metal complexes were characterized on the basis of elemental analysis and micro analytical datas. Shift in the characteristic spectral frequency of the metal complexes, confirms the coordination through metal ion with azomethine group. They were screened for antibacterial activity against several bacterial strains namely E. coli(-), S. aureus(+) M. luteus(+) and B. lichenformis(+) (ATCC), the metal complexes showed enhanced antibacterial activity compared to uncomplexed ligand.
This article can be downloaded from www.ijpbs.net P - 240
KEY WORD
Antibacterial activity, Amoxicillin trihydrate.
INTRODUCTION
Compound containing imines bases have not only found extensive application in organic synthesis,1-2 but several of these molecules display significant biological activity. In the last decade Schiff base ligands 3-6 have received more attention mainly because of their wide application in the field of catalysis and due to their antimicrobia, 11-12 anti-tuberculosis7 and anti-tumor activity. They easily form stable complexes with most transition metal ion.13-14 The development of the field of