In order for this study to be conducted 399 males subjects with syphilis and 201 male subjects without were tested.
And in order to gain the cooperation of the unknowing subject “They were told they were ill and were promised free care. Offered therapy, they became willing subjects” (Brandt 5) but the drugs they received were mostly ineffective or insufficient dosages. The USPHS did not inform the men that they were part of an experiment and wanted to maintain their interest until they could perform the final procedure which was a spinal tap to test for neurosyphilis. Because of the study, the subjects were denied actual medical treatment from other doctors most of the men who weren't in the control group had their life expectancy decreased by about twenty percent and “more than 30 percent of the test group autopsied had died directly from advanced syphilitic lesions” (Brandt
6) Things that made the Tuskegee syphilis study unethical where mainly the facts that the USPHS prevented the men from receiving proper treatment and nor did they even contemplate providing the subjects with penicillin or any other medicine which was available at the time. Arguably the most prevalent issue with the experiment was the fact that all 500 subjects were not given the opportunity to give their consent to participate in the study nor were any of them informed about the experiment which meant that the men did not submit to the experiment voluntarily. Major repercussions of the study are the realization that the notion that science is a value-free discipline has to be rejected and that there has to be great vigilance when assessing the impact of social values and attitudes on professional behavior.
The Tuskegee study violates much of the Nuremberg Code the most obvious of which are number one and four The first point of the Code essentially states that the subjects should be knowledgeable enough to understand risks, be given the legal capacity to give their consent, and should not be tricked or pressured into agreeing to terms an example would be in Taking the Least of You ‘“circle I do” (Skloot 4) to trick Moore to agree. The study violates this because they relied upon not knowledgeable people to become their subjects and they did not inform the subject about the experiment which means they didn't have free power of choice nor did they give their consent. The fifth point states that there should not be any experiment conducted with a definite probability of death or disabling injury. The Tuskegee study violates this since the whole point of the study was to observe what happened to a deadly disease when left untreated.By not treating the disease a minimum of twenty percent of the subjects died which is not supposed to happen.