Preview

Summary: The Endocannabinoid System

Satisfactory Essays
Open Document
Open Document
159 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Summary: The Endocannabinoid System
The discovery of the major psychoactive ingredient in cannabis, tetrahydrocannabinol, or THC, was in 1964 by Israeli Scientist Dr. Raphael Mechoulam (Backes 17). Researchers later discovered a complex network within our bodies that respond to chemicals similar to THC, that our own bodies produce known as endocannabinoids. Closely related to the widely known Omega 3 fatty acid, endocannabinoids modulate and regulate numerous functions and systems of the body such as pain, stress, and anxiety levels. The endocannabinoid system is responsible for eliminating aversive memories within the amygdala, the part in the brain whose function regulates fear and emotional memory. A recent study demonstrated that “abnormal endocannabinoid signaling in the

You May Also Find These Documents Helpful

  • Good Essays

    Delta 9-tetrahydrocannabinol (THC) affects the brain and in turn the body through receptors called endocannabinoids. These receptors are can be found in multiple areas of the brain and lymphatic tissues. Extensive research has found that marijuana users are able to consume more foods with lot of calories and less nutritional content and still maintain a normal body mass index better than or similar to non-marijuana users. The reasoning behind this hypothesis is centered around the observation is that the occurrence of Diabetes Mellitus would be lessen in people who use marijuana since their bodies contain components from the marijuana that helps to users to control and regulate the digestive system in addition to preventing inflammation of…

    • 261 Words
    • 2 Pages
    Good Essays
  • Powerful Essays

    Cannabis is the most commonly used drug in the UK after alcohol and tobacco, however only 1 in 8 adults and 1 in 5 young people have admitted to using it in the last year (FRANK, 2013). The main active ingredients in cannabis are delta-9-tetrahydrocannabinol (THC) and this is what causes the ‘high’ and cannabidiol (CBD) which acts as a counterbalance, making you feel alert and creative (Alexandrou, 2011). THC is the main ingredient which has been linked to causing long-term neuropsychological damage. During the past 10 years, stronger strains of cannabis have become more popular, with an increase from 6% to 16 % THC with less CBD (Alexandrou, 2011). This is thought to have caused an increase in cannabis related neuropsychological harm. Much of the leading research into the long-term effects of marijuana, suggests that regular, long-term use of marijuana leads to deficits in IQ, executive functioning, motor and learning skills and short-term memory loss(Grant, Gonzalez, Carey, Natarajan, & Wolfson, 2003; Pope, Gruber,& Yurgelun-Todd, 1995; Pope, Gruber, Hudson, Huestis, & Yurgelun-Todd, 2001; Solowij & Battisti, 2008; Grant et al., 2003; as cited by Nehal P. Vadhan, Wilfred G. van Gorp, and Frances R. Levin 2011; Solowij, 2002; Harvey, Sellman, Porter & Frampton, 2007). However, there are debates among the critics as to how ‘long-term’ these effects are, who they are most likely to affect and the cause of the neuropsychological damage.…

    • 1257 Words
    • 6 Pages
    Powerful Essays
  • Good Essays

    The use of illegal drugs in the twenty-first century is very common. Cannabis, also known as marijuana, and other well-known names, are among the most frequently used drugs today. Marijuana comes from cannabis sativa, which is a hemp plant. The plant contains a chemical which is known as tetrahydrocannabinol (THC). Some people smoke marijuana in hand-rolled cigarettes or in pipes or water pipes while other mix marijuana in foods such as brownies, cookies, or candy, or brew it as a tea. There are a few benefits of using cannabis. It’s used as a medicinal drug and can minimize physical pain and alleviate psychological disorders, such as anxiety and depression. However, the use of cannabis…

    • 1806 Words
    • 8 Pages
    Good Essays
  • Good Essays

    1. Attention, memory and learning are impaired among heavy marijuana users, even after users discontinued its use for at least 24 hours. Heavy marijuana use is associated with residual neuropsychological effects even after a day of supervised abstinence from the drug. Heavy users displayed significantly greater impairment than light users on attention/executive functions, as evidenced particularly by greater preservations on card sorting and reduced learning of word lists. These differences remained after controlling for potential confounding variables, such as estimated levels of premorbid cognitive functioning, and for use of alcohol and other substances in the two groups. However, the question remains open as to whether this impairment is due to a residue of drug in the brain, a withdrawal effect from the drug, or a frank neurotoxic effect of the drug. ("The Residual Cognitive Effects of Heavy Marijuana Use in College Students," Pope, HG Jr., Yurgelun-Todd, D., Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA, JAMA February 21, 1996.)…

    • 1325 Words
    • 6 Pages
    Good Essays
  • Good Essays

    Depressive illness is widespread and exhibits a lifetime prevalence rate of 16% (Kessler et al. 2003). Depressive illnesses can be characterized by an array of disturbances, emotional behavior, memory, neuro-vegetative functions and hedonic processing. The neurobiological mechanisms subserving the development, manifestation and treatment of depression are complex, and there is ample evidence that disturbances in monoaminergic signaling, glucocorticoid activity and neurotrophic/neuroplastic processes are involved (Ressler and Nemeroff 2000; Holsboer 2000; Duman and Monteggia 2006; McEwen 2005). A wide range of people I know suffer from depression and currently use prescribed medication in order to alleviate the symptoms; for this reason, I chose this article. Cannabinoids are a diverse class of compounds that activate cannabinoid receptors CB1 and CB2. I want to explore the effect of cannabinoids on people who have been subjected to Chronic Unpredicted Stress (CUS). This CUS is one of the leading causes of depression in teenagers.…

    • 630 Words
    • 3 Pages
    Good Essays
  • Better Essays

    R. Mechoulam et al. 2003. Cannabidiol: an overview of some pharmacological aspects. Neuroscience Letters 346: 61-64; J. McPartland and E. Russo. 2002. Cannabis and cannabis extracts: greater than the sum of their parts. Journal of Cannabis Therapeutics 1: 103-132; A. Zuardi and F Guimaraes. Cannabidiol as an anxiolytic and antipsychotic. In: M. Mathre (Ed): Cannabis in medical practice: a legal, historical and pharmacological overview of therapeutic use of marijuana. McFarland Press: 1997: 133-141.…

    • 3286 Words
    • 9 Pages
    Better Essays
  • Good Essays

    In the book “Cannabis and Cannabinoids” that Franjo Grotenhermen wrote in 2002, which mostly deals with the medical aspects of marijuana. There was a study that was recorded about the effects that THC the active ingredient in marijuana and the results were a little surprising. Marijuana was found to treat a wide range of various ailments such as: Tourette-Syndrome, appetite loss, weight loss, nausea, depression, HIV-infection, migraines, asthma, back pain, hepatitis C, sleeping disorders, epilepsy, spasticity, headaches,…

    • 982 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Endogenous ligands, or endocannabinoids, exist in cell membranes and are produced naturally within an individual when they are needed. Endocannabinoids act as neurotransmitters and bind to the receptors in the endocannabinoid system. There are five endocannabinoids, N-arachidonyl-dopamine (NADA), 2-arachidonylglyceryl ether (noladin ether), O-arachidonyl-ethanolamine (virodhamine), arachidonylethanolamide (anandamide) and 2-arachidonoyl glycerol (2-AG). The two most important, and highly reviewed endocannabinoids, both derived from arachidonic acid, are anandamide (arachidonylethanolamide) and 2-AG (2-arachidonoyl glycerol). Anandamide is a CB1 receptor partial agonist with a chemical structure, and behavioral characteristics, similar to THC. In addition to binding to cannabinoid receptors, NADA and Anandamide stimulate the transient receptor potential vanilloid subtype 1 (TRPV1) in relation to CB1 receptors.…

    • 211 Words
    • 1 Page
    Good Essays
  • Powerful Essays

    One of the main societal issues revolved around medical marijuana is the effect it has on individuals emotionally. Using marijuana is like putting a wet blanket over human emotions, it separates a person’s conscious thoughts from their feelings, dissociating one’s thinking from the realistic world. This temporary sign effect can be quite dangerous to those unaware of their emotional makeup. For some the drug can relieve stress, relax the body and mask depression by providing feelings of euphoric happiness. While for others it can leave a feeling of anxiousness, fear and paranoia.…

    • 1079 Words
    • 4 Pages
    Powerful Essays
  • Good Essays

    Synthetic Cannabinoids

    • 635 Words
    • 3 Pages

    Synthetic cannabinoids act on the same brain cell receptors as delta-9-tetrahydrocannabinol (THC), the mind-altering ingredient in marijuana.…

    • 635 Words
    • 3 Pages
    Good Essays
  • Better Essays

    Mikuriya, T. (2006). Cannabis eases post traumatic stress. Retrieved December 06, 2009 from Mikuriya: http://www.mikuriya.com/cw_ptsd.html.…

    • 2162 Words
    • 9 Pages
    Better Essays
  • Good Essays

    In the past year, many medicinal benefits of marijuana have been discovered. Two scientists from the California Pacific Medical Center “found that a compound derived from marijuana could stop metastasis in many kinds of aggressive cancer” (Wilkey). One of the scientists discovered Cannabidiol, found in marijuana, also works with other types of aggressive cancers that have high levels of ID-1 present. Cannabidiol is also used to help with anxiety and nausea. Marijuana, which can also be used to help all fight obesity related diseases, contains an ingredient called THCV, and when this substance and Cannabidiol is introduced into a person’s system, it can help suppress hunger. Also, “tests in mice show the compounds boost the animal’s metabolism, [which led] to lower levels of fat in the livers and reduced cholesterol in the blood stream. THCV also increase[d] the animal’s sensitivity to insulin” (Gray).…

    • 477 Words
    • 2 Pages
    Good Essays
  • Good Essays

    Marijuana Exploratory

    • 928 Words
    • 4 Pages

    “The Marijuana Initiative Is a Silent Killed and It Should be Defeated – Los Angeles, March 25/PRNewswire/.”_PR Newswire: Press Release Distribution, Targeting, Monitoring and Marketing. _Web. 08 Apr. 2010.…

    • 928 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Marijuana Effects On Teens

    • 1116 Words
    • 5 Pages

    The brain of the average human is not done developing until the age of 25 or 26 therefore teen smokers risk directly affecting the process of their developing brain (URMC). According to NIDA for Teens (NIDAT) chronic use of the drug can lead to damage in the hippocampus, a key component of the brain as well as an 8 point drop in IQ in recent studies. By damaging the hippocampus one may affect the ability to learn and can also damage memory as these are two of the main functions of the hippocampus. Analyzing the effects of THC which alters information received in the hippocampus can also explain the difficulty to create memories while high. With steady use these difficulties in memory can become long lasting and also bring along troubles in judgement as well as cognitive impairment. The American Psychological Association (APA) states that short term effects of marijuana on the brain include impaired functions such as attention, memory, learning and decision-making. With the brain under construction during teen years any cessation to development can crucially impact the final outcome as being high can be considered a cessation of brain development. Since the brain is developing the short term affects can last longer in an adolescent’s brain slowing reaction time even days after being high. Furthermore according to Health Line (HL) there may be a link between depression and anxiety to the use of Marijuana. Previous generations argue that their brains were not dramatically affected while growing up on Marijuana however according to the Trusted Teen Treatment (TTT) versions of Marijuana today contain more THC than those available in the 1970’s, containing up to 10% THC. With this said the effects of the higher THC can only be hoped to be prevented as the result are in the…

    • 1116 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Week 3 Appendix J

    • 536 Words
    • 3 Pages

    The stronger mixes of marijuana have the same types of unpleasant mental responses such as hallucinogens (Hollister, 1971).…

    • 536 Words
    • 3 Pages
    Good Essays