Synthesissed Quinoxaline-2, 3-Dione Lab Report
Objective: The target of this study was to evaluate the anthelmintic and antimicrobial activity of synthesissed quinoxaline-2,3-Dione.
Methods:
The anthelmintic activity of selected newly synthesized 2, 3-dioxo-1, 2, 3, 4-tetrahydro quinoxaline-6-sulfonyl benzimidazole (s) were performed on adult earthworm (Pheretima Posthuma). The observation was made for the time taken to paralysis and/or death of individual worms up to four hours of the test period. Paralysis was said to occur when the worms did not revive even in a vehicle. Death was concluded when the worms lost their motility followed with fading away of their body color. The selected newly synthesized 2, 3-dioxo-1, 2, 3, 4-tetrahydro quinoxaline-6-sulfonyl benzimidazole (s) compounds …show more content…
It was found that quinoxaline- 2, 3-dione -6-sulphonyl benzimidazole (s) have pronounced effect as compared to plain quinoxaline -2,3-dione against worms, the gram positive and gram negative bacteria. Among all the compounds, 2, 3-dioxo -1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl (2-acetyl) benzimidazole have been exhibited good activity in the dose of 20 mg/ml against earth worm, bacteria and fungi like standard drug. This may be due to presence acetyl moiety in the benzimidazole ring conjugated with quinoxaline-2, 3- dione pharmacophore …show more content…
They are part of various antibiotics such as Echinomycin, Levomycin, and Actinoleucin which are known to inhibit the growth of gram-positive bacteria and also active against various transplantable tumors [1]. They are known to possess other biological potentials such as anthelmintic [2], antimicrobial [3], adenosine receptor antagonist, anticancer, antidepressant, anti-inflammatory, and antitubercular activity [4, 5]. Quinoxaline and its mode of action that prevent DNA-directed RNA synthesis by virtue of binding to cpG site on DNA [6].Interestingly, some 2-sulphonylquinoxalines and 3- [(alkylthio) methyl] quinoxaline 1-oxide derivatives were reported to be endowed with antibacterial and antifungal activities
Methods:
The anthelmintic activity of selected newly synthesized 2, 3-dioxo-1, 2, 3, 4-tetrahydro quinoxaline-6-sulfonyl benzimidazole (s) were performed on adult earthworm (Pheretima Posthuma). The observation was made for the time taken to paralysis and/or death of individual worms up to four hours of the test period. Paralysis was said to occur when the worms did not revive even in a vehicle. Death was concluded when the worms lost their motility followed with fading away of their body color. The selected newly synthesized 2, 3-dioxo-1, 2, 3, 4-tetrahydro quinoxaline-6-sulfonyl benzimidazole (s) compounds …show more content…
It was found that quinoxaline- 2, 3-dione -6-sulphonyl benzimidazole (s) have pronounced effect as compared to plain quinoxaline -2,3-dione against worms, the gram positive and gram negative bacteria. Among all the compounds, 2, 3-dioxo -1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl (2-acetyl) benzimidazole have been exhibited good activity in the dose of 20 mg/ml against earth worm, bacteria and fungi like standard drug. This may be due to presence acetyl moiety in the benzimidazole ring conjugated with quinoxaline-2, 3- dione pharmacophore …show more content…
They are part of various antibiotics such as Echinomycin, Levomycin, and Actinoleucin which are known to inhibit the growth of gram-positive bacteria and also active against various transplantable tumors [1]. They are known to possess other biological potentials such as anthelmintic [2], antimicrobial [3], adenosine receptor antagonist, anticancer, antidepressant, anti-inflammatory, and antitubercular activity [4, 5]. Quinoxaline and its mode of action that prevent DNA-directed RNA synthesis by virtue of binding to cpG site on DNA [6].Interestingly, some 2-sulphonylquinoxalines and 3- [(alkylthio) methyl] quinoxaline 1-oxide derivatives were reported to be endowed with antibacterial and antifungal activities