At first, the Taino and Columbus and his men were civil. The Taino actually treated the new men with hospitality and kindness. Which some believe causes their undoing.
Columbus started enslaving the natives and treating them with cruelty. Thus started the massive amounts of death. The Taino started fighting back, causing lots of deaths. As well as being exposed to diseases they had no immunity too. This cause 85% of the Taino population to either die out or disappear.
This also affected European culture in many ways. Including