Brinton (2016) study suggests that “multiple neurodegenerative diseases are associated with decline in mitochondrial function, e.g., Alzheimer’s, Parkinson’s, multiple sclerosis and multiple neuropathies” (p. 1); implies that mitochondria perform very important function to keep our brain healthy and functional. Alzheimer is a progressive neurodegenerative disease is most common cause of adult dementia. One of the reasons of Alzheimer’s disease is that brain doesn’t receive enough oxygen due to mitochondrial dysfunction. APOE4 genotype are carriers prone to Alzheimer’s disease since “has been associated with mitochondrial dysfunction and glucose hypometabolism in brain” (Wang and D. Brinton, 2016, p.7). APOE4 fragments cause mitochondrial dysfunction because it can interact with mitochondria directly which is one of the causes of neurotoxicity. Wang and D. Brinton (2016) research suggests that women are at higher risk of Alzheimer disease since some mitochondrial genetic variances associated with AD only found in
Brinton (2016) study suggests that “multiple neurodegenerative diseases are associated with decline in mitochondrial function, e.g., Alzheimer’s, Parkinson’s, multiple sclerosis and multiple neuropathies” (p. 1); implies that mitochondria perform very important function to keep our brain healthy and functional. Alzheimer is a progressive neurodegenerative disease is most common cause of adult dementia. One of the reasons of Alzheimer’s disease is that brain doesn’t receive enough oxygen due to mitochondrial dysfunction. APOE4 genotype are carriers prone to Alzheimer’s disease since “has been associated with mitochondrial dysfunction and glucose hypometabolism in brain” (Wang and D. Brinton, 2016, p.7). APOE4 fragments cause mitochondrial dysfunction because it can interact with mitochondria directly which is one of the causes of neurotoxicity. Wang and D. Brinton (2016) research suggests that women are at higher risk of Alzheimer disease since some mitochondrial genetic variances associated with AD only found in