al.
2015). When it is not phosphorylated it stays inactive and can cause problems in memory coding. If protein phosphate-1 is not activated then there will also be an issue in memory because it will not activate cAMP-response element binding protein. What activates protein phosphate-1 is DARPP-32. DARPP-32 is linked to Calpain, through activating DARPP-32. If Calpain is inhibited by calpeptin then it will stay in its inactive form and not cleave DARP-32. By not cleaving DARP-32 it will stay inactive as well, resulting in an inactive form of cAMP-response element binding protein. Which as said earlier will cause a problem in coding short-term memory into long-term memory, which is a calling card of Alzheimer’s. So down regulation of Calpain, has a cascade effect which helps form Alzheimer’s (Cho et al.
2015).