THE ROLE OF PROTEIN MISFOLDING AND AGGREGATION IN BSE
THE ROLE OF PROTEIN MISFOLDING AND AGGREGATION IN BSE
When a protein misfolds it changes its behavior and function. If it becomes hydrophobic after once being polar. The properties and functionality of the protein are no longer useful to the organism and disaster results.
PrPSc is hydrophobic, it avoids water inside of the cell…it attracts and attaches other proteins to misfolds and become hydrophobic …Misfolding spreads because the PrPSc act as chaperone proteins to convert PrPc TO PrPSc and cannot be converted back to PrPc. The normal homeostasis would be reached and health regained by PROTAEOSOMES (protein destroyers) eating the corrupt PrPSc proteins BUT..These are not recognized by the proteasomes and so are not destroyed. They keep multiplying and they clump together and aggregate inside the cell and the cell stops doing its normal work and eventually it dies.
Prion - Wikipedia, the free encyclopedia. (n.d.). Retrieved November 23, 2013, from http://en.wikipedia.org/wiki/PrPSc
How enzymes work
Enzymes are complex protiens whose main function is to reduce or speed up the energy required for a reaction to occur. This happens thru the enzymes ability to break or form a bond within a substance that results in 1 or 2 new substances without changing the protein configuration of the enzyme itself – this keeps the enzyme available to continue its work.
The area on the enzyme where the work takes place is called the active site. The specific molecule that becomes transformed is called a substrate. http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter2/animation__how_enzymes_work.html
citric acid cycle enzyme lack
It seems to me that enzymes with the suffixes dehydrogenase break up substances and sythetase combine substances to make new products
(http://biochemistryatitsbest.wordpress.com/2013/04/06/cori-cycle-review/, n.d.)
Anaerobic Glycolysis occurs when there is continuing muscle activity. This produces some ATP for
When a protein misfolds it changes its behavior and function. If it becomes hydrophobic after once being polar. The properties and functionality of the protein are no longer useful to the organism and disaster results.
PrPSc is hydrophobic, it avoids water inside of the cell…it attracts and attaches other proteins to misfolds and become hydrophobic …Misfolding spreads because the PrPSc act as chaperone proteins to convert PrPc TO PrPSc and cannot be converted back to PrPc. The normal homeostasis would be reached and health regained by PROTAEOSOMES (protein destroyers) eating the corrupt PrPSc proteins BUT..These are not recognized by the proteasomes and so are not destroyed. They keep multiplying and they clump together and aggregate inside the cell and the cell stops doing its normal work and eventually it dies.
Prion - Wikipedia, the free encyclopedia. (n.d.). Retrieved November 23, 2013, from http://en.wikipedia.org/wiki/PrPSc
How enzymes work
Enzymes are complex protiens whose main function is to reduce or speed up the energy required for a reaction to occur. This happens thru the enzymes ability to break or form a bond within a substance that results in 1 or 2 new substances without changing the protein configuration of the enzyme itself – this keeps the enzyme available to continue its work.
The area on the enzyme where the work takes place is called the active site. The specific molecule that becomes transformed is called a substrate. http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter2/animation__how_enzymes_work.html
citric acid cycle enzyme lack
It seems to me that enzymes with the suffixes dehydrogenase break up substances and sythetase combine substances to make new products
(http://biochemistryatitsbest.wordpress.com/2013/04/06/cori-cycle-review/, n.d.)
Anaerobic Glycolysis occurs when there is continuing muscle activity. This produces some ATP for