Smooth muscle contraction occurs when calcium is present in the smooth muscle cell and binds onto calmodulin to activate myosin light chain kinase (Wilson et al., 2002). Phosphorylation of myosin light chains result in myosin ATPase activity thus cross-bridge cycling occurs causing the muscle to contract (Horowitz et al., 1996). There are two known models of excitation and contraction in smooth muscle, electromechanical coupling (EMC) and pharmomechanical coupling (PMC) (Droogmans et al., 1997). EMC involves a change in membrane potential as a result of nerve stimulation (Sanders, 2008). Depolarisation causes voltage gated calcium channels to open and contraction occurs. High potassium (K+) concentration causes potassium leak channels to shut down thus no positive charge leaves the cell and the membrane becomes depolarised (Morgan et al., 1981). It is possible to determine if a tissue uses EMC, by depolarising the tissue and seeing if it contracts. Depolarisation of smooth muscle cells through the EMC can be achieved when a K+-depolarisation solution is used as a stimulus, causing calcium release and contraction. On the other hand, PMC does not require a change in membrane potential (Edman, 1962). Rather, drugs mediate smooth muscle contraction, for example acetylcholine (Ach) that bind onto receptors and cause the calcium into the smooth muscle cell causing it to contract (Devine et al., 1972, Sanders, 2008).…