These events dramatically affect the plot for the better or the worse. The dome coming down affects the setting in multiple ways. The small town of Chester Mills is now cut off from the rest of civilization and is on its own. The dome going up also affects the plot and storyline. It affected the storyline in ways like allowing the survivors to escape and return to civilization where they were meet by family and friends.
Another event would be when the meth lab blows up. That explosion resulted in the deaths of