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Against effect of melatonin and its combination with therapeutic exercise on
Doxorubicin induced Cardiotoxicity

Tserentogtokh Lkhagvasuren1, Seunghoon Lee2, Jeong-Hwa Hong1, and Yonggeun Hong2,3.
1Department of Smart Foods & Drugs, Inje University, 2Department of Rehabilitation Science, Inje University, 3Cardiovascular & Metabolic Disease Center, Inje University, Gimhae, Gyeongnam 621-749, Korea

Abstract

Doxorubicin (DOX) has been known as strong therapeutic effective in cancers. DOX induced oxidative stress may cause necrosis apoptosis and left ventricular dysfunction and cardiac toxicity. We have known that melatonin protects against DOX induced cardiac damage. Also therapeutic exercise potential improve the ejection, left ventricle filling, due to reduction of myocardial oxidative stress by exercise. Thus, the purpose of this study was to determine synergistic effect of melatonin and exercise in DOX induced cardiac disease animal model. Cardiac toxicity was induced by i.p. injection of DOX. At 2-week after induction, the rats were randomly divided into 4 groups as follow; vehicle, melatonin, exercise, and melatonin with exercise. It was decreased left ventricle mass and increased ratio of heart/tibia in melatonin and exercise group compared to vehicle group. Single treated with melatonin or exercise group shown protective effect against DOX induced cardiac damage whereas DOX induced cardiac inflammation was significantly higher in vehicle group. Taken together, melatonin and exercise have synergistic protective effect on DOX induced cardiac damage suggesting that melatonin and DOX co-treatment is beneficial to reduce side effect of DOX in heart

Keywords; Melatonin, doxorubicin, therapeuticexercise, ….

Introduction

Doxorubicin (DOX) or Adriamycin is a cancer drug, one of the most widely used successful chemotherapeutic agent for cancers, including breast, prostate and hepatocellular carcinoma. However its clinical use is limited that dose

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