Whooping Cough (Pertussis) is an infection of the respiratory system caused by bacterium Bordetella pertussis. It’s characterized by severe coughing spells, which can sometimes end in a “whooping” sound when the person breathes in.
How does it Affect the Body? * Whooping Cough (Pertussis) is an infection of the upper respiratory system. * prevents natural defense systems from removing germs * causes mucus accumulation * The bacterium also populates the breathing tubes in the lung, inflaming and narrowing them. * The characteristic "whoop" cough is due trying to inhale through the narrow, inflamed airways. * The inability to draw breath may cause a red- or blue-colored face and exhaustion.
Incubation Period
The incubation period (the time between infection and the onset of symptoms) for whooping cough is usually 7 to 10 days, but can be as long as 21 days.
Predominate Area of the Body
Pertussis is predominantly an upper respiratory infection.
It does What to our Cells? * Bordetella pertussis releases Pertussis Toxin. * When engulfed by a cell via endocytosis, it will escape into the cell where it will catalyze ADP-Ribosylation of G proteins that participate in G-Protein Coupled Receptors. * This, in effect, inhibits signalling in the cells
Vectors * There is no vector. * Transmission is only human to human. * Pertussis is spread from person to person through the inhalation of aerosol droplets of infected nasal and throat discharges released during coughing and sneezing.
Symptoms * The first symptoms of pertussis are similar to a cold: sneezing, a runny nose, possibly a low-grade fever, and a cough. After one or two weeks, the cough becomes severe as noted by the following: * The cough occurs in sudden, uncontrollable bursts where one cough follows the next without a break for breath. * Many children will make a high-pitched