Why Do Sickle Red Cells Cause Anemia?

Sickle-Cell Anemia is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin. These hemoglobin molecules tend to aggregate after unloading oxygen forming long, rod-like structures that force the red cells to assume a sickle shape. Unlike normal red cells, which are usually smooth and malleable, the sickle red cells cannot squeeze through small blood vessels. When the sickle cells block small blood vessels, the organs are deprived of blood and oxygen. This leads to periodic episodes of pain and damages the vital organs. Sickle red cells die after only about 10 to 20 days. Instead of the usual 120 days because they cannot be replaced fast enough, the blood is chronically short of red cells, causing anemia. The gene for sickle cell anemia must be inherited from both parents for the illness to occur in children. A child with only one copy of the gene may have sickle-cell traits but no symptoms of illness.
Normally healthy blood cells are round shaped blood cells, they move through small blood vessels to carry oxygen to all parts of the body. People with sickle-cell disease their blood cells are not round they are become hard and sticky and look like a C-shaped farm tool called a “sickle”. The sickle cells die early, which causes a constant shortage of red blood cells. Also, when they travel through small blood
Sickle-cell disease is mostly inherited by African Americans, Mediterranean countries; Greece, Turkey, and Italy; the Arabian Peninsula, India, and Spanish-speaking regions; South America, Central America, and parts of the Caribbean. The three most common forms of the disease in the United States are Hemoglobin SS or sickle cell anemia, Hemoglobin SC disease, and Hemoglobin sickle beta-thalassemia (a form of "Cooley 's"