Write An Essay On Parkinson's

Before discussing treatments, it is important to understand the general characteristics and causes of Parkinson's. Recall that it is a progressive disorder of the central nervous system that affects the motor system and usually initiated by the slight noticeable tremor of a hand. Early stages may consist of face showing little to no expression and arms not swinging at all for motor balance during walking; decreasing ability to perform unconscious movements such as blinking and smiling. Take Greg for example, he made it clear that when someone smiles at him, he thinks he smiles back when he really doesn't. "It's something I just can't do at the movement and I have to try really hard to perform that simple action that everyone can do just fine," he says. Tremors are a big issue in Parkinson's that may start in a limb (hand or fingers) to back-and-forth rubbing of the
One can interpret neuronal loss by analyzing the reduction of neuromelanin, which is the pigment that allow us to visualize the condition of the substantia nigra. A key pathological feature of Parkinson's is based off the microscopic anatomy of the substantia nigra showing Lewy bodies, which are irregular collections of protein that form inside neurons, appearing as spherical masses that take up the space of cellular components (Iacono, et al., 2015). You can think of it as a blood clot that doesn't allow the passage of blood through a vessel. Besides that, neuronal loss is accompanied by the death of astrocytes, which play a key role in nourishing endothelial cells that form the blood brain barrier and activation of microglia, which are the macrophages part of the central nervous system's immune defense. The downside of microglial activation is chronic inflammation that is the fundamental process in contributing to the death of dopamine producing neurons, a characteristic destructive process (Qian, Flood,