Zellweger Spectrum Disorder

Zellweger Spectrum Disorder is a group of overlapping symptoms and signs that affect many parts of the body. This group of disorders includes Zellweger syndrome (most severe), neonatal adrenoleukodystrophy (intermediate), and infantile Refsum disease (least severe) because these different groups are so similar doctors prefer to just refer to these disorders as severe, intermediate, and mild. Symptoms that present themselves throughout the levels of severity include weak muscle tone, feeding problems, seizures, intellectual disabilities, developmental delay, vision and hearing loss. Children with this condition also present with life-threatening problems in the tissues and organs, such as liver, kidneys, and heart. Skeletal abnormalities, large