A Journal Critique on the Synthesis of New Derivatives of Resveratrol and to Explore its Potential Health Benefits
A Journal Critique on the Synthesis of New Derivatives of Resveratrol and to Explore its Potential Health Benefits
Summary
The goal of the study is to extract and purify resveratrol from fresh skin of black grapevine. Resveratrol is a member of a group of plant compounds called polyphenols and belongs to the class called stilbene. Resveratrol is produced by grapes and some plants in response to stress, injury, fungal or bacterial attack and ultraviolet radiation. Studies show that it makes chemotherapy more effective, weaken viruses including influenza and HIV (Adams, 2011). It could also counter the effects of a high-fat diet and increase physical endurance, which some scientists believes that it is one of the factors behind the French Paradox or the concept that despite of the high intake of dietary cholesterol and saturated fat, there is a low percentage of coronary heart disease mortality in France (Ferrières, 2004). In rodent studies, a mice fed with a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by imitating the effects of caloric restriction (Maddox, 2012). Resveratrol also incredibly lengthen the lifespan of worms, yeast, and some fishes (Adams, 2011). In the experiment, local black grapes were gathered and were classified as Vitis vinifera. The skin was separated from the fruit and was placed in dark, cool area. To avoid oxidation of the plant extract, the steps were done away from direct light. The skin was shaken with ethyl acetate and was kept for 72 hours and was filtered. The filtrate was dried using a rotary evaporator to get one-tenth of its original amount. The functional and phenolic groups present in the resveratrol were tested using standard methods. Aromaticity and the melting point were also determined. In the preparation of the resveratrol derivatives, the first two resveratrol extracts were dissolved in dry benzene. To
Summary
The goal of the study is to extract and purify resveratrol from fresh skin of black grapevine. Resveratrol is a member of a group of plant compounds called polyphenols and belongs to the class called stilbene. Resveratrol is produced by grapes and some plants in response to stress, injury, fungal or bacterial attack and ultraviolet radiation. Studies show that it makes chemotherapy more effective, weaken viruses including influenza and HIV (Adams, 2011). It could also counter the effects of a high-fat diet and increase physical endurance, which some scientists believes that it is one of the factors behind the French Paradox or the concept that despite of the high intake of dietary cholesterol and saturated fat, there is a low percentage of coronary heart disease mortality in France (Ferrières, 2004). In rodent studies, a mice fed with a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by imitating the effects of caloric restriction (Maddox, 2012). Resveratrol also incredibly lengthen the lifespan of worms, yeast, and some fishes (Adams, 2011). In the experiment, local black grapes were gathered and were classified as Vitis vinifera. The skin was separated from the fruit and was placed in dark, cool area. To avoid oxidation of the plant extract, the steps were done away from direct light. The skin was shaken with ethyl acetate and was kept for 72 hours and was filtered. The filtrate was dried using a rotary evaporator to get one-tenth of its original amount. The functional and phenolic groups present in the resveratrol were tested using standard methods. Aromaticity and the melting point were also determined. In the preparation of the resveratrol derivatives, the first two resveratrol extracts were dissolved in dry benzene. To
References: Adams, M. (2011). Amazing food fact: Miracle nutrient resveratrol is synthesized by grapes in response to fungal attacks. Retrieved February 18, 2013, from Natural News: http://www.naturalnews.com/033905_resveratrol_grapes.html Bertelli AA, et al. (1995). Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4 ',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Retrieved February 27, 2013, from Europe PubMed Central: http://www.europepmc.org/abstract/MED/9063768 Bertelli AA, et al. (1996). Antiplatelet activity of synthetic and natural resveratrol in red wine. Retrieved February 27, 2013, from Europe PubMed Central: http://www.europepmc.org/abstract/MED/7499059 Ferrières, J. (2004). The French paradox: lessons for other countries. Retrieved February 18, 2013, from NCBI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768013/ Lu, R. & Serrero, G. (1999). Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. Retrieved February 27, 2013, from Wiley Online Library: http://www.onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-4652(199906)179:3%3C297::AID-JCP7%3E3.0.CO;2-P/abstract Maddox, T. (2012). Resveratrol Supplements. Retrieved February 18, 2013, from WebMD: http://www.webmd.com/heart-disease/resveratrol-supplements