cell and cancer worksheet

Virtual Lab: The Cell Cycle and Cancer
Worksheet

1. In which phase of mitosis do each of the following occur:
a. Centromeres split and chromosomes move toward opposite sides of the cell anaphase b. Chromatin coils to form visible chromosomes prophase c. The nuclear membrane disappears prophase d. Sister chromatids line up in the center of the cell metaphase 2. In which phases of mitosis are sister chromatids visible, and attached to each other at the centromere?
Prophase and metaphase

Table 1: Record your data for the number of cells in each stage of the cell cycle observed in normal tissues.

Tissue Type
# Cells in Interphase
# Cells in Prophase
# Cells in
Metaphase
# Cells in Anaphase
# Cells in
Telophase
Lung Tissue
Sample 1
19
0
0
1
0
Lung Tissue
Sample 2
19
0
0
1
0
Stomach Tissue
Sample 1
18
0
1
0
1
Stomach Tissue
Sample 2
16
1
1
0
2
Ovarian Tissue
Sample 1
17
0
1
2
0
Ovarian Tissue
Sample 2
19
0
0
1
0

Table 2: Record your data for the number of cells in each stage of the cell cycle observed in cancerous tissues.

Tissue Type
# Cells in Interphase
# Cells in Prophase
# Cells in
Metaphase
# Cells in Anaphase
# Cells in
Telophase
Lung Tissue
Sample 1
16
0
2
1
1
Lung Tissue
Sample 2
15
1
3
0
1
Stomach Tissue
Sample 1
13
2
2
2
1
Stomach Tissue
Sample 2
14
2
1
1
2
Ovarian Tissue
Sample 1
11
2
2
3
2
Ovarian Tissue
Sample 2
13
2
1
2
2

Table 3: Use the data in Table 1 to calculate the Mitotic Index (average % cells dividing) for each normal tissue type.

Tissue Type
Avg. % cells at rest
Mitotic Index
Lung - normal
95
5
Stomach - normal
85
15
Ovary - normal
90
10

Table 4: Use the data in Table 2 to calculate the average % cells dividing and average % cells at rest in each cancerous tissue type.

Tissue Type
Avg. % cells at rest
Mitotic Index
Lung - cancerous
32
23