class note
Electron transport and oxidative phosphorylation
1. The mitochondrion
Lec 8
A. Mitochondrial anatomy
B. Mitochondrial transport systems
2. Electron transport
A. Thermodynamics of electron transport
B. The sequence of electron transport
Lec 9
C. Complex I NADH Coenzyme Q Oxidoreductase
D. Complex II succinate Coenzyme Q Oxidoreductase
E. Complex III Coenzyme Q-Cytochrome c Oxidoreductase
F. Complex IV Cytochrome c oxidase
3. Oxidative Phosphorylation
A. The Chemiosmotic Theory
Lec 10
B. ATP Synthase
C. The P/O ratio
D. Uncoupling oxidative phosphorylation
4. Control of ATP Production
A. Control of oxidative phosphorylation
B. Coordinated control of oxidative metabolism
Lec 11
5. Physiological implications of aerobic metabolism
A. Cytochrome P450
B. Reactive Oxygen Species
C. Antioxidant Mechanisms
Mitochondria and chloroplasts are organelles of energy conversion that carry their own DNA
Mitochondria – release energy from nutrients and convert it to ATP
Chloroplasts – capture solar energy and store it in carbohydrates
Organelles in a cell
Mitochondria
Mitochondria are membrane-enclosed organelles distributed through the cytosol of most eukaryotic cells.
Their main function is the conversion of the potential energy of food molecules into ATP.
Every type of cell has a different amount of mitochondria.
There are more mitochondria in cells that have to perform lots of work, for example - your leg muscle cells, heart muscle cells etc.
Other cells need less energy to do their work and have less mitochondria.
Mitochondrion
Size: 0.5 x 1.0 µm
Copy number per cell: ~2000
Particles: portion of integral membrane proteins The mitochondrion
Cristae are sometimes tubular and are connected to the inner membrane space through small holes that restrict the flow of protons. This restriction causes an increase in the pH gradient and increases the ATP production.
Outer and Inner membrane of
1. The mitochondrion
Lec 8
A. Mitochondrial anatomy
B. Mitochondrial transport systems
2. Electron transport
A. Thermodynamics of electron transport
B. The sequence of electron transport
Lec 9
C. Complex I NADH Coenzyme Q Oxidoreductase
D. Complex II succinate Coenzyme Q Oxidoreductase
E. Complex III Coenzyme Q-Cytochrome c Oxidoreductase
F. Complex IV Cytochrome c oxidase
3. Oxidative Phosphorylation
A. The Chemiosmotic Theory
Lec 10
B. ATP Synthase
C. The P/O ratio
D. Uncoupling oxidative phosphorylation
4. Control of ATP Production
A. Control of oxidative phosphorylation
B. Coordinated control of oxidative metabolism
Lec 11
5. Physiological implications of aerobic metabolism
A. Cytochrome P450
B. Reactive Oxygen Species
C. Antioxidant Mechanisms
Mitochondria and chloroplasts are organelles of energy conversion that carry their own DNA
Mitochondria – release energy from nutrients and convert it to ATP
Chloroplasts – capture solar energy and store it in carbohydrates
Organelles in a cell
Mitochondria
Mitochondria are membrane-enclosed organelles distributed through the cytosol of most eukaryotic cells.
Their main function is the conversion of the potential energy of food molecules into ATP.
Every type of cell has a different amount of mitochondria.
There are more mitochondria in cells that have to perform lots of work, for example - your leg muscle cells, heart muscle cells etc.
Other cells need less energy to do their work and have less mitochondria.
Mitochondrion
Size: 0.5 x 1.0 µm
Copy number per cell: ~2000
Particles: portion of integral membrane proteins The mitochondrion
Cristae are sometimes tubular and are connected to the inner membrane space through small holes that restrict the flow of protons. This restriction causes an increase in the pH gradient and increases the ATP production.
Outer and Inner membrane of