Sickle cell anemia affects people with African, Mediterranean, Middle Eastern, and Indian ancestry (Scientific American). Sickle cell anemia occurs when a person inherits two sickle cell gene, one from each parent, that cause the red blood cells to change and become crescent shaped. The underlying problem involves hemoglobin, a component of the red blood cells. Hemoglobin is a protein molecule in red blood cells that carries oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lung. In sickle cell anemia, the hemoglobin is flawed (The New York Times). As a result, the cells become sickle shaped and can’t travel as easily through blood vessels. Sickle cell anemia is an illness, which has one primary cause, but a variety of symptoms and treatments (Scientific American.) Like some illnesses, sickle cell anemia has one primary cause. In order for sickle cell anemia to occur is when a sickle cell gene have, been inherited from both the mother and the father, so that the child has two sickle cell gene. The sickle cell gene causes the body to make abnormal hemoglobin. As mentioned above, hemoglobin is a protein molecule in red blood cells that carries oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lungs. A person with normal red blood cell will have hemoglobin A; however, a person with sickle cell disease will have hemoglobin S…
1. Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.…
Cells in tissues need a constant supply of oxygen to work well. RBC’s that contain typical hemoglobin are disc shaped and flexible so that they can move through large and small blood vessels to deliver oxygen to our organs. Atypical hemoglobin found in sickle celled patients are often compared to stiff rods or sickled shape. The problem with the shape is that these cells are not flexible and can stick and cling to vessel walls, causing an impasse that slows or in some cases completely stops the flow of blood. When this happens, oxygen can’t reach nearby tissues and our bodies go into failure mode.…
Sickle cell anemia is the most common form of sickle cell disease which is an inherited, autosomal recessive disorder that causes an abnormal hemoglobin cell. The person with this specific disorder inherited hemoglobin S from both parents, also known as homozygous (Lewis, Dirksen, Heitkemper, & Bucher, 2014, pp. 644-647). This hemoglobin S results from the substitution of valine for glutamic acid on the B-globin chain of hemoglobin, and this ultimately causes the erythrocyte to stiffen and elongate taking a sickle shape in response to low oxygen levels (Lewis et al., 2014, pp. 644-647). Due to the sickle cells elongated shape, and its stiff and sticky consistency it tends to get stuck in capillaries and vessels, and blocks blood flow to limbs and organs (Lewis et al., 2014, pp. 644-647). The major problems with sickle cell anemia is due to their sickled shape, reduced life expectancy and their ability to carry enough hemoglobin or transport it properly to…
Sickle cell anemia is a disease where your body produces abnormally shaped red blood cells. The cells are shaped like a crescent or sickle used to cut wheat. As the sickle cell blood cells don't last as long as normal round red blood cells this then leads to anemia. The sickle cells can also get stuck in blood vessels, blocking blood flow and are unable to get oxygen around the body effectively.…
Sickle cell disease is an inherited disorder in which red blood cells are abnormally shaped. This abnormality can result in painful episodes, serious infections, chronic anaemia, and damage to body organs.…
Sickle cell hemoglobin exists as isolated units in the red blood cells when they have oxygen bound. However, when they release it in the peripheral tissues, due to valine, the molecules tend to stick together and form a polymer (long inflexible chain) which distorts the cell and causes it to bend out of shape. While most distorted cells are simply shaped irregularly, some of them have a crescent (or sickle)-like shape which gives it the disorder the name sickle cell anemia. When the red blood cells pick up oxygen again the chain breaks and the haemoglobin molecules are isolated…
Sickle-cell disease is a commonly known genetic disorder that puts the life at risk of millions of people across the world. This disorder can be classified as a monogenic disorder that results from…
Sickle Cell Anemia, also known as Sickle Cell Disease, is a disease that causes the production of abnormal hemoglobin. The red blood cells (RBCs) carry oxygen to organs and tissues. Hemoglobin, a molecule in the RBCs, is a protein that attaches to the oxygen in the lungs and carries it to all parts of the body. Hemoglobin takes on the oxygen, and releases carbon dioxide, a process known as oxygenation. In the tissues, deoxygenation occurs where the processes is reversed, when hemoglobin releases oxygen and takes on carbon dioxide. When the RBCs are healthy, they can easily move through the tiniest blood vessels throughout the body because of their flexibility. The hemoglobin S is fragile and abnormal in Sickle Cell Anemia, and the RBCs are pointy with a shape like the alphabet letter "C" or the crescent moon. This makes the RBCs difficult to move pass through the blood vessels. The RBCs become hard, and can get stuck in blood vessels, and often clog the spleen. This causes pain, infection, and poor blood flow in patients that have Sickle Cell Anemia. The RBCs also block blood flow to organs, such as the heart, lungs, brain, etc., which can lead to stroke, damage to organs, especially the spleen, acute chest syndrome, disability, and sometimes, even death.…
INTRODUCTION: “Pain” sudden or chronic, lasting from a few hours to a few days; from a few weeks to a few months evolving from an adhesive substance in red blood cells. The “Pain” is inherited by an retriction blood flow through the body do to an abnormality in the cells. “Sickle Cell Anemia” a chronic illness discovered in 1910 by an American physician named James Bryan Herrick. Sickle Cell is more that just pain; it is a disease that is affected by abnormal blood cells that has an adhesive formation causing the natural flow to be compromised. As a result, these abnormal cells become fixed in the blood stream and not flowing to major body organs causing extreme pain and even a stroke. Why is this process painful? Have sickle cell patient become tolerant to pain or is it because some of them handle self-care management? For many years there has been a link between Sickle Cell Anemia and Pain caused by the stickiness of the blood cells. When this occurs, it decreases normal blood flow to the major organs causing strokes.(citation ). Sickle cell anemia is most common in people whose families come from Africa, South or Central America (especially Panama), Caribbean islands, Mediterranean countries (such as Turkey, Greece, and Italy), India, and Saudi Arabia. In the United States, it's estimated that sickle cell anemia affects 70,000–100,000 people, mainly African Americans. The disease occurs in about 1 out of every 500 African American births. Sickle cell anemia also affects Hispanic Americans. The disease occurs in more than 1 out of every 36,000 Hispanic American births (Citation).More than 2 million Americans have sickle cell trait. The condition occurs in about 1 in 12 African Americans. In people with sickle cell disease, approximately 50% do not survive beyond age 20 years, and most people do not live past 50 years of age (Citation)…
Sickle cell disease is an autosomal recessive genetic disorder most common in African Americans, which results from a mutation affecting the amino acid sequence of the beta chains of hemoglobin molecules in red blood cells. The abnormal hemoglobin which causes the red blood cells to sickle is called hemoglobin S. Sickling occurs when the red blood cells are deoxygenated causing the cell to have a hard curved crescent shape. Due to their shape the sickle cells can become trapped in blood vessel walls causing a circulatory blockage and could cause tissues to become oxygen deprived, pain, infection, and organ damage. Red blood cells in sickle cell disease also have a life span of 10 to 20 days compared to normal red blood cells of 120 days; because of this shortened life span chronic hemolytic anemia occurs (Thompson, 2012). All together sickle cells disease causes a dramatic decrease in the quality of life that can lead to early death, the absolute need for medical intervention, and transplantations.…
Sickle cell is inherited and is normally only found in Black Americans. The blood cells are shaped differently and it due to a genetic defect. (WebMD, 2014) This causes the blood cells to eliminate themselves rather quickly causing lack of oxygen to the organs in the body. The reason this disease is so painful is because the blood cells become trapped in the blood vessels. (WebMD, 2014)…
Sickle cell anemia or also known as sickle cell disease is a hereditary genetic disease defined by the presence of odd shaped crescent-shaped red blood cells instead of the regular round disc like shape cells. Red blood cells transport oxygen from the lungs to various other organs and tissues with the help of a protein called hemoglobin. The main cause of sickle cell disease is when hemoglobin mutates into an abnormal type called hemoglobin S. The presence of Hemoglobin S causes red blood cells to be sickle-shaped and rigid, making it more difficult for them to flow through blood vessels in the body to deliver oxygen. Therefore, the sickled cells latch onto the walls of various blood vessels throughout the body, resulting in blocked blood flow that can lead to organ damage, pain and infections…
with the Sickle Cell disease, and based on these studies, the longevity and quality of life of these patients have greatly improved (Wethers, 2000). It has been researched and proven that Sickle Cell Anemia…
Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shape. The “sickling” occurs because of a mutation in the hemoglobin gene. Sickle cells are stiff and sticky. They tend to block blood flow in the blood vessels of the limbs and organs. Blocked blood flow can cause pain, serious infections, and organ damage. Life expectancy in people who have this disease is shortened.…