coactivator: Nuclear receptors contains one ligand dependent transcriptional activation domain AF-2. Upon the agonist binding‚ AF-2 take an active conformation that allow it to bind the coactivators. AF-2 consists of the hydrophobic residues of helices 3‚ 4‚ 5 and 12. So‚ when the agonist is binding‚ helix 12 would take a conformation that allow it to complete the hydrophobic surface of AF-2 allow binding to LXXLL motifs of the coactivator [3]. The nuclear receptors are different in which motif
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What type of medication is prescribed to diabetics? Insulin. 2. What type of medication is prescribed to diabetics? For human insulin‚ it is consists of two polypeptide chains in which the chain A has 21 amino acids and chain B has 30 amino acids (Beta Cell Biology Consortium‚ 2014). Other than that‚ the two polypeptide chains are connected by two inter-chain disulfide bridges (Beta Cell Biology Consortium‚ 2014). For insulin from other animals‚ the structure is almost the same as human insulin‚ the
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presidents and there has been many good president’s that we have learned about through time. The first president of the United States was George Washington and many people liked him for all sorts of reasons but the main reason everyone liked him because he was a good leader. George Washington had his falls just has many other people do because we are only human and he was in charge and had to make some very powerful decisions. Before we get into why George was a good president you should know that he
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enjoyed reading blogs. I love reading about other people’s experiences and knowing we all go through life’s good and bad moments together (some of us just choose to share with the rest of the blog world). One of the blogs I regularly read has recently begun promoting and featuring different products. While she has always had advertising banners in the margins of her blog‚ more recently she has begun featuring products within her actual blog posts. I thought this would be a great topic to explore in my
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While reading Fahrenheit 451‚ it became clear to see the many reasons why it was a banned book at one point. Ray Bradbury includes multiple remarks about religion‚ specifically the Bible and the superior power God. He not only includes talk of religion but also makes it clear that the society which Montag lives in is clearly corrupt‚ but for most of the people within that society‚ it seems perfectly stable. What may be completely shocking to some when they first read Fahrenheit 451 may be the fact
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join in the war. Two reasons why it was necessary was to make sure that the Allies payed their debts to the United States and to stop the Germans from wanting to take away the U.S. shipments. 2) I agree because they need to protect themselves and to make sure that they can trust the Allies. Also so they know that everything is in check and nothing will go wrong since they are helping the Allies. I think it was a smart decision because they are looking out for the good of their selves the U.S. 1)
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Market dominance strategies Market dominance strategies are marketing strategies which classify businesses by reference to their market share or dominance of an industry. What is market dominance? Market dominance is a measure of the strength of a brand‚ product‚ service‚ or firm‚ relative to competitive offerings. There is often a geographic element to the competitive landscape. In defining market dominance‚ you must see to what extent a product‚ brand‚ or firm controls a product category
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especially in the late 1800s to the early 1900s‚ imperialism was a prevailing affair in the world. Imperialism is a policy of extending a country’s power and influence through diplomacy or military force‚ and it was used in political‚ economic‚ and social ways. Since the 1400s‚ people have debated over the most prominent reason of the cause of imperialism. Some believe that political reasons started the enthusiasm to seize smaller nations‚ while others argue that its cause was economical or social. All three
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the South. During this time‚ there was much debate going on about whether slavery should exist or whether it should be demolished. These articles show two completely different opinions on slavery and whether it should exist. Hammond was proslavery and defended slavery against the abolitionists. Meanwhile‚ Helper was an abolitionist and argued against slavery. In response to abolitionists‚ Hammond offered some interesting opinions. The opinion that intrigued me the most was that one of his arguments
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started to wonder if the US was going to join the war. Here are three reasons why it wasn’t inevitable that the US wouldn’t join WWI. The first reason why it was not inevitable was that the trade business was booming. From both sides they had ports saved for us merchant ships and were blocked off for others entering. The main people that were trading with though was the United Kingdom and Germany. Since they were trading with these two countries specifically their market was going up and they were expanding
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