vial attached to an air condenser to synthesize crude acetaminophen‚ resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken‚ and found to be 165.9 - 170.9°C and 168.2 - 171.5°C‚ respectively. The literature melting point of acetaminophen is 169.5 – 171.0°C‚ indicating that our final product was
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Score 2. Acetaminophen (C8H9NO2) is the active ingredient in many nonprescription pain relievers. Each tablet contains 500 mg of acetaminophen‚ and a typical adult dose is two tablets every eight hours. ● Determine the molar mass of acetaminophen (show your work). ● Calculate the number of moles of acetaminophen in a single tablet (show your work). ● Calculate the number of moles of acetaminophen that an adult would have taken if she took three doses of acetaminophen in one day (show your work)
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History 3 2.12 chemical structures 4 2.2 The background information of Acetaminophen 5 2.21 History 5 2.22 Chemical Structures 6 3.0 BODY 6 3.1 Synthesis 6 3.11 Synthesis of Aspirin 6 3.12 Synthesis of Acetaminophen 7 3.2 Mechanism of Action in Human Body 9 3.2.1 Pain as a warning system 9 3.2.2 Aspirin 9 3.2.3 Acetaminophen 10 3.3 Side effects 10 3.3.1 Side effects of Aspirin 10 3.3.2 Side effects of Acetaminophen 11 4.0 EVALUATION AND RECOMMENDATIONS 12 5.0 CONCLUSION 13 6.0 BIBLIOGRAPHY
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Mechanisms of Acetaminophen-lnduced Liver Necrosis By Jack A. Hinson‚ Dean W. Roberts‚ and Laura P. James Acetaminophen (paracetamol‚ N-acetyl-p-aminophenol; APAP) is widely used as analgesic and antipyretic drug. At therapeutic doses‚ acetaminophen is safe to be used. Acetaminophen other than aspirin and ibuprofen has only weak anti-inflammatory properties. At higher doses‚ acetaminophen produces a centrilobular hepatic necrosis that can be fatal. Acetaminophen-lnduced Hepatotoxicity Observation/
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Contents 1.0 Abstract Acetaminophen and aspirin are both well-known drugs that relieve pain and reduce fever. This report looks at acetaminophen as a potential substitute for a patient who is allergic to aspirin. Acetaminophen‚ a common analgesic drug that can be bought over the counter‚ was synthesised by Hormon Northrop Morse. With acetaminophen consisting of a benzene ring‚ an amide and an alcohol group‚ it has the ability to stop pain and reduce fevers. However‚ due to the state of technology
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The kidney and the liver are two of the four major routes a drug takes when trying to leave the body. If someone has kidney or liver disease‚ how a person’s body handles that drug is greatly affected. Drinks‚ food and or lifestyle habits that put added stress and cause damage to your kidneys or liver‚ foe example alcohol abuse or chronic exposure to toxins such as paint fumes‚ can affect how well you process drugs. Kidney and or liver stress/damage usually raises drug levels a lot higher than normal
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utilize the principles of cyclic voltammetry to determine technique accuracy in calculating the actual concentration of an acetaminophen elixir. Five standard solutions of acetaminophen and an acid buffer solution were created and analyzed with a potentiostat to determine the peak anodic voltage and current during the scanning process. Three solutions of Tylenol®—containing acetaminophen—and acid buffer were then created and scanned at the same scan rate as the five standard solutions. Additionally‚ the
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of pain relievers‚ Acetaminophen‚ have emerged into the market and its growth in the market seemed quite significant compared to that of aspirin type pain relievers. Although acetaminophen comprised of less than 10% Analgesic market‚ its Sales were growing at a rate of 50% where Aspirin was only growing at a rate of 9%. Bristol-Myers clearly saw an opportunity in Acetaminophen market and hence they are planning to launch Datril‚ acetaminophen type pain reliever. Acetaminophen pain reliever has
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(ibuprofen‚ aspirin‚ acetaminophen‚ caffeine) and the unknown in isopropyl alcohol (IPA)‚ and developing the plates in acetone. Rf values were calculated for each compound. The unknown tablet showed an Rf value of 0.584‚ closely matching that of caffeine (0.600)‚ suggesting similar polarity. The findings indicated that the unknown tablet likely contains caffeine or a closely related compound. Materials and Methods The materials required to complete
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We underwent two different reaction schemes using Dipotassium phosphate (K2HPO4) and Potassium hydroxide (KOH) to isolate the compounds of pure Acetylsalicylic Acid/Aspirin and N-(4-hydroxyphenyl) Ethanimidate/Acetaminophen respectively from Excedrin. The first reaction scheme to undergo acid-base organic extraction was to isolate the most acidic compound in Excedrin with a weak base‚ K2HPO4. We isolated the aspirin using aqueous base extraction‚ with Dipotassium phosphate then treated with HCl
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