Paracetamol - a curriculum resource Frank Ellis RSeC ROYAL SOCIETY OF CHEMISTRY Paracetamol - a curriculum resource Compiled by Frank E llis Edited by Colin Osborne and Maria Pack Designed by lmogen Bertin Published by the Royal Society of Chemistry Printed by the Royal Society of Chemistry Copyright 0 Royal Society of Chemistry 2002 Registered charity No. 207890 Apart from any fair dealing for the purposes of research or private study‚ or criticism or review‚ as permitted under
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Panacetin‚ a type of pain-killer. Panacetin is typically made up of sucrose‚ aspirin‚ and acetaminophen‚ but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen‚ either acetanilide or phenacetin. Using techniques such as extraction‚ evaporation‚ and filtration‚ the three components will be isolated based on their solubilities and acid-base properties. Then‚ the percent composition of Panacetin can be deduced based on the masses
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Experiment 1: separating components of a counterfeit pharmaceutical Aim Counterfeit pharmaceuticals are a big concern regarding the issue of medicines due to fake versions containing either the wrong ingredients or inaccuracy of the active ingredient which can cause toxicity issues in patients using these products. The aim of this experiment
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2-naphthol‚ and naphthalene. These organic solids are purified by partitioning the solid in 2 immiscible solvents‚ diethyl ether and sodium bicarbonate or sodium hydroxide. II. Significance a. The significance of the Extraction lab is to purify Acetanilide benzoic acid‚ 2-naphthol‚ and naphthalene by determining the partition coefficient. This value is determined by dividing the solubility of the given solute in the extraction solvent (Sodium bicarbonate or Sodium hydroxide)) by the solubility in
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properties. To obtain such a pure compound‚ the compound we want must be separated from its other natural components‚ which can be done by manipulating physical and chemical properties. Panacetin contains sucrose‚ aspirin and an unknown which can be acetanilide or phenacetin in which phenacetin was created and weighed. Introduction In this lab our basic goal was to make the sucrose‚ aspirin and unknown that are formed from pharmaceutical panacetin. In doing this lab we used NaOH and diethyl either‚ along
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The objective of this lab was to identify an unknown compound by determining the melting point range using fast and slow ramps. Also‚ to determine the eutectic point of Urea and Cinnamic Acid. An unknown compound that was numbered 8 was chosen. A small amount of the unknown compound was placed in a weighing paper using a spatula. The weighing paper was folded in half twice and then was grinded using a spatula. After the unknown compound was grinded about 1-2mm was added into a capillary tube. A
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Sulfa Drugs: Preparation of Sulfanilamide Introduction The purpose of this experiment is to prepare sulfanilamide from p-Acetamidobenzenesulfonyl chloride. This will be done using reflux‚ vacuum filtration‚ and melting point determination. Experiment Scheme6 Figure 1. Reaction equation.6 A hot water bath was prepared in a fume hood using a 250-mL beaker. 2.5 g of p-acetamidobenzenesulfonyl chloride was placed into a 50 mL Erlenmeyer flask and 11 mL of dilute ammonium hydroxide solution
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To get to aniline‚ tin metal acts as a reducing agent and is oxidized to SnCl4. The purification of crude aniline is done by distillation and extraction. Aniline can be converted to acetanilide by acetylation reaction using acetic anhydride with sodium acetate. This step protects the amine functional group from doing unwanted reactions during chlorosulfonation and amination steps. The chlorosulfonyl group attacks in the para position
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Separating The Components of “Panacetin” Observations Most natural products and many commercial preparations are mixtures containing a number of different substances. To obtain a pure compound from such a mixture‚ you must separate the desired compound from the other components of the mixture by taking advantage of differences in their physical and chemical properties. Acidic or basic substances are often converted to water-soluble salts‚ which can then be separated from the water-insoluble
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a boiling chip to any liquid before heating it. • Always wear department approved eye goggles at all times. • Long pants and closed toe shoes are required. Table of Reagents Reagent Mol. Wt. (g/mol) Bp ( ͦ C) Mp ( ͦ C) Density (g/ml) Acetanilide 135.17 304 113-115 1.219 Fluorene
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