This yields sodium salicylate which will be acidified in methanol (CH3OH) which will remove the sodium bonded to the oxygen‚ and switch it to a hydrogen atom bonded to the oxygen‚ making an alcohol group. This new product is salicylic acid. Acetic anhydride is added to the salicylic acid to add an acetyl group to carbon 2 which will create acetylsalicylic acid
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Investigating Aspirin Aims Synthesize my own aspirin Analyse the purity of my aspirin samples (aspirin and recrystallized aspirin) compared to commercial aspirin by use of analysing melting points‚ TLC plates and colorimetry tests Investigate how pH effects the rate of hydrolysis of aspirin Background theory Making my own sample of Salicylic acid (to then be converted into Aspirin) Salicylic acid (2-Hydroxybenzoic acid) can be made by hydrolysing methyl 2-hydroxybenzoate. Oil
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Preparation of Sodium Chloride through titration Abstract: acid-base titration is a technique commonly used to determine the moles of acid in a sample by adding a known volume of strong base of a known concentration. The strong base provides the hydroxide ion‚ to react quantitatively with the acid. The point at which the acid is completely and exactly consumed the known quantity of base is called the equivalence end point and is signalled by a colour change in the solution (end point). This colour
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In the formation of acetylsalicylic acid (Aspirin)‚ salicylic acid and acetic anhydride were made to react in the presence of an acid catalyst‚ namely sulfuric acid. In the formation of methyl salicylate (oil of wintergreen)‚ salicylic acid and methanol were reacted together in the presence of the same acid catalyst‚ sulfuric acid
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Acetaminophen Data: p-aminophenol: 0.150g Weight of crude acetaminophen 0.122g Weight of purified acetaminophen 0.060g Weight of crystallized acetaminophen 0.028g Melting point range for dried crude product 166.8-167.6°C Melting point range for final crystallized product 166.1-169.8°C Melting point range for pure Acetaminophen 169.5-171°C Results: After first isolation of crude acetaminophen‚ 1.22g of
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It also has very low toxicity is it is used properly. Acetaminophen is cheap and easily obtainable from any pharmacy. Acetaminophen is created when the amine group of p-aminophenol is acetylated by acetic anhydride. This creates an amide functional group and the by-product of this reaction is acetic acid. The crude acetaminophen will form as a white solid after the acetylated reaction. To turn this crude acetaminophen into a purified form‚ the recrystallization technique will be used. The recrystallization
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Our data displayed supports the notion that by increasing the acidity of the catalyst‚ the production of aspirin will increase. Our hypothesis was proven correct. In our data‚ we calculated the percent yield and percent error of each trial. We also calculated the average of the percent yields and the percent errors of each catalyst. In the end‚ we saw that for the sulphuric acid catalyzed aspirin‚ we saw an average of 69.7% percent yield and an average 30.3% percent error. As for the phosphoric acid
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melting point of 135°C and is also known to be aspirin. It is one of the most widely used drugs that can lower fever and is used as a painkiller. According to (Escobel‚ 2011)‚ Aspirin is synthesized through the reaction of salicylic acid with acetyl anhydride that causes a chemical reaction that turns salicylic acid’s hydroxyl group into an acetyl group‚ (R—OH → R—OCOCH3). An inorganic acid such as phosphoric acid is used as a catalyst. Set-ups Figure 1.1. Steam bath Figure 1.2. Cold bath Figure
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recrystallization‚ and comparing the properties of aspirin with salicylic aspirin. The first thing we did in this lab was make a hot-water bath by putting a beaker with water on a hot plate. After measuring out 2.1 grams of salicylic acid and 3 ml of acetic anhydride‚ we mixed the two together‚ along with 3 drops of sulfuric acid. We then put the flask containing the mixture into the hot-water bath‚ and heated it for 10 minutes. After removing the flask from the hot water‚ we added 2 mL of distilled water
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of a colored iron(III)-salicylate complex was determined using spectrometry‚ and then the percents from each process was compared. Acetylsalicylic acid is produced when salicylic acid and acetic anhydride react in the presence of H2SO4. Consequently‚ the said reaction produces acetylsalicylic acid and acetic acid. In part one of the lab‚ titration of a NaOH solution with an indicator and a known concentration into a solution containing
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