Abstract Tamoxifen‚ most commonly sold under the brand name Nolvadex‚ is the most widely used drug in the treatment of breast cancer during both early and late stages. It belongs to a class of drugs known as SERMs (Selective Estrogen Receptor Modulators). SERMs work by blocking the estrogen receptors in breast cells to prevent any binding with estrogen. It is consumed orally as a tablet or as a liquid (Anon.‚ 2017). The following paper discusses the discovery of Tamoxifen‚ its laboratory synthesis
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General Features of Oxidative Additions Oxidative addition reactions usually involve a coordinatively unsaturated 16-electron metal complex or five-coordinate 18-electron species‚ and take the general from: [pic] If the A and B ligands in the product are considered to be formally –1‚ then the metal center has increased its oxidation state by +2‚ and this is the origin of the name oxidative addition. Oxidative reaction can occur when a metal complex
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NPC Natural Product Communications Phenolic Composition‚ Antioxidant Capacity and Antibacterial Activity of Selected Irish Brassica Vegetables 2011 Vol. 6 No. 9 1299 - 1304 Amit Kumar Jaiswal‚ Gaurav Rajauria‚ Nissreen Abu-Ghannam* and Shilpi Gupta School of Food Science and Environmental Health‚ College of Sciences and Health‚ Dublin Institute of Technology‚ Cathal Brugha Street‚ Dublin 1‚ Ireland nissreen.abughannam@dit.ie Received: November 28th‚ 2010; Accepted: May 22nd‚ 2011
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involved On the nitrogen atom ‚ so that the term alkaline and π - pyridine compounds are described for defects . Pyridine ring through the nitrogen. The reaction is typically weak ‚ organic tertiary amines such as protons ‚ alkylation ( see ) ‚ and acylation. 3.Pyridine and alkyl pyridines liquid are considered a dipolar aprotic solvent like dimethylformamide or dimethyl sulfoxide. Most Pyridine- water azeotrope formation with significant ‚ separation of pyridine by steam distillation of the mixture
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Paclitaxel (PTX) Paclitaxel (PTX)‚ a member of taxane family‚ it’s an effective antineoplastic agent for treatment of many forms cancer. The success of PTX in these diseases due to a broad spectrum of antitumor activity‚ efficacy in terms of dense disseminated tumours and a unique mechanism of action. This microtubule-stabilizing drug selectively disrupts the microtubule forces‚ which induces mitotic arrest that leads to cell death(Bernabeu et al. 2017). A brief run through of its development from
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Acetylcholinesterase and Butyrylcholinesterase substrate selectivity and various acting cholinesterase inhibitors Introduction Cholinesterases are a group of enzymes present in mammals which breakdown certain neurotransmitters by hydrolyzing the ester bonds within a molecule (Rang & Dale‚ 2007). There are two major types of enzymes‚ acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Though similar in structure‚ they differ in distribution‚ function and substrate specificity. AChE is
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TETRAHEDRON LETTERS Tetrahedron Letters 39 (1998) 9279-9282 Pergamon Efficiencies of Reductive Amination Reactions on Different Solid Supports Chinh T Bui‚ Firas A. Rasoul‚ Francesca Ercole‚ Yen Pham and N Joe Maeji* Cluron TechnologiesPry Ltd.. 11 Duerdin Street. Cla.~aon‚Vic. 3168‚ Australia Received 12 August 1998; accepted 1 October 1998 Abstract: Rreductive amination on resins derivatized with 5-(4-forntyl-3‚5-dimethoxyphenoxv)valeric acid linker (Barallv linker‚ 1) 1 has been
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MATERIALS REVOLUTION UNIT REVISION BOOKLET Vikram Mahal How To Use this Booklet: This booklet has been created by addressing all the points on the OCR B salters specification for the section‚ what’s in medicine. I advise reading through the Book‚ highlighting or underlining words written in ALL CAPITALS. I also suggest making a spider diagram or mind map to summarise key points and help the information here stick in your mind. You could also draw your own images by points on this
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CHM456 ORGANIC CHEMISTRY 1 LABORATORY Contact hours: 3 hours/week Laboratory textbook: Pavia‚ Lampman‚ Kriz and Engel‚ Introduction to Organic Laboratoy Techniques 3rd Edition (2011) ** Students MUST obtain a copy of the textbook Synopsis This is an organic chemistry practical course which reinforce the theory and concepts studied in Organic Chemistry 1 (CHM456). It covers the learning of simple laboratory techniques such as reflux‚ distillation‚ extraction‚ crystallization and melting point
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Benzene 1 Benzene Benzene Identifiers [1] CAS number 71-43-2 PubChem 241 ChemSpider 236 UNII J64922108F EC number 200-753-7 KEGG C01407 ChEBI CHEBI:16716 ChEMBL CHEMBL277500 RTECS number CY1400000 Jmol-3D images Image 1 [2] [3] [4] [5] [6] [7] [8] [9] Properties Molecular formula CH Molar mass 78.11 g mol−1 Appearance Colorless liquid Odor aromatic‚ gasoline-like
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