these genes leads to increased production of PRPP. Thus‚ excess purine nucleotides are being formed which leads to increased purine metabolism resulting in enhanced production of uric acid and as a consequence hyperuricemia and gout. A glucose 6- phosphatase deficiency can result in Von Gierke disease. The inability to dephosphorylate glucose 6-phosphate leads to an increased activity in the pentose phosphate pathway. Enchanced production of ribose 5 phosphate results in substrate level activation of
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Organ Motion: RT of thoracic and abdomino-pelvic targets poses difficulties of precise target localisation and patient positioning. There is considerable variation in patient position and organ location during planning and treatment. This could be due to difficulties in precise positioning‚ and immobilisation‚ patient movement and organ motion. Consequently there is a chance of deviation in the dose absorbed from the actual planned dose to be delivered. Accurate understanding of the details of organ
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5. What determines where a protein kinase or protein phosphatase will perform its enzymatic activity? Answer: As protein kinase and protein phosphatase are the enzymes‚ they both perform their enzymatic activity by interacting at the specific binding site on the protein. Both of the enzymes recognize the specific amino acid sequence around the amino acid that is to be either phosphorylated or dephosphorylated respectively. 6. Why would a signaling pathway need to be regulated? Answer: Signaling
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The Endocrine Society’s CliniCal Guidelines Osteoporosis in Men: An Endocrine Society Clinical Practice Guideline Authors: nelson B. Watts‚ Robert a. adler‚ John P. Bilezikian‚ Matthew T. drake‚ Richard eastell‚ eric s. Orwoll‚ and Joel s. Finkelstein Affiliations: Mercy Health Osteoporosis & Bone Health services (n.B.W.)‚ Cincinnati Ohio 45236; McGuire Veterans affairs Medical Center and Virginia Commonwealth university school of Medicine (R.a.a.)‚ Richmond‚ Virginia 23298; Columbia
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Glucose homeostasis The fed state Presentation copyright © 2007 David A Bender The central nervous system is very largely reliant on glucose as its metabolic fuel; it cannot oxidise fatty acids (but can metabolise ketone bodies in prolonged starvation) glycogen Red blood cells are absolutely reliant on glucose; they have no mitochondria and form ATP only by anaerobic glycolysis triacyglycerol protein glucose triacylglycerol in VLDL triacylglycerol in chylomicrons amino
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smoking as much as she used to. She has also noticed that her urine is darker than usual and she has yellowing of her eyes. She has noted that she has a puffy appearance. Results of blood tests at her doctor’s office reveal that her ALT‚ AST ‚ alkaline phosphatase‚ and bilirubin levels are elevated and that she also has an elevated count of lymphocytes. Further tests reveal that she is positive for the presence of the anti-HCV in her blood. Biopsy reveals necrosis‚ fibrosis‚ and cirrhosis. What
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Abstract Background: Tamoxifen (TMX) is a synthetic drug that is used for treatment of breast cancer. Despite the beneficial effects of TMX‚ the use of this drug has several side-effects in these patients. Non-alcoholic fatty liver disease (NAFLD) is a well-known adverse effect of TMX. Silybum marianum is the most researched plant in the treatment of liver disease. Objectives: In this study the effect of Silybum marianum extract (SME) on histological and biochemical parameters in the TMX treated
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RICKETS For Scientific Principles and Health and Disease By: Mackenzie Gray 112-69-7540 April 7‚ 2010 Rickets is a disease that deals with a deficiency with Vitamin D. Vitamin D is important by controlling calcium and phosphate levels. If the blood levels of these minerals become too low‚ the body may produce hormones that cause calcium and phosphate to be released from the bones eventually this leads to weak and soft bones. (2) Throughout this paper we will go over a variety
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receptors are ligand-activated ion channels that permit entry of ions when the central pore is open. According to Hofmeyer (2009)‚ receptor protein tyrosine phosphatases control many aspects of nervous system development. At the Drosophila neuromuscular junction‚ regulation of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and on the extracellular ligands syndecan and
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Makati Medical Center College of Nursing DRUG STUDY Patient’s Name: M.D.C. Age: 42 y/o Medical Diagnosis: Leptospirosis Attending Physician/s: M.T Allergies: none Allergic Responses: none Prepared by: Shiela Guiquing |DRUG NAME |MECHANISM OF ACTION |RATIONALE FOR THIS PATIENT |ADVERSE DRUG EFFECT |NURSING IMPLICATIONS | |
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