Design and Materials Gili Heriawan Farahsyifa Mutiara Khansa Khaula Muhammad Rausyan Fikri Ajeng R.P. Rizki Ihza P. Designing New Medicinal Drugs • What we need to know ? • Identify the structural features of the active site for particular enzyme associated with the pathogen. • Determine the functional groups present to ensure effective binding of the drug. • Intermolecular bonds of drugs-activesite : • Hydrogen bond • Ionic attraction • Dipole-dipole forces • Van der Waals’
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representative spectra of CNAgNPs obtained where absorption peaks are located at about 3383cm-1(-OH groups of Carboxylic acids and also –N-H groups of amines)‚ 2131cm-1(-CΞN‚CΞC‚-C-H strech)‚1786 cm-1(-C=O of ketones and esters)‚1643 cm-1(-C=O of amides and carboxylic acids stretch )‚1045 cm-1(-C=O of esters). Fig. 4 FTIR Spectra of Cocos nucifera Silver Nanopparticles (CNAgNPs) 3.4. XRD Analysis X-ray Diffraction (XRD) analysis confirmed the existence of crystalline silver nanoparticles in the
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Bioquímica Repaso Examen 1 Chapter 1: Introduction to Biochemistry 1.1 Biochemistry is a Modern Science • By synthesizing urea‚ Friedrich Wöhler showed that compounds found in living organisms could be made in the laboratory from inorganic substances. He used the inorganic compound ammonium cyanate. • Two major breakthroughs in the history of biochemistry are especially notable: o Roles of enzymes as catalysts o Roles of nucleic acids as information carrying molecules.
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Bio 1011 Cells Exam #1 Answer the multiple choice questions on the scantron sheet. Select the one choice that best answers the question. Answer the short answer questions in the space provided at the end of the exam. 1. Which of the following is the SMALLEST? a. a bacterium b. a ribosome c. a hexose sugar d. a water molecule e. a yeast cell 2. The four main families of small inorganic molecules in cells are a. salts‚ sugars‚ fatty acids‚ amino acids‚ nucleotides b.
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IUBMB Life‚ 53: 85–98‚ 2002 Copyright c 2002 IUBMB 1521-6543/02 $12.00 + .00 DOI: 10.1080/10399710290038972 Review Article Structural Basis of Perturbed pKa Values of Catalytic Groups in Enzyme Active Sites Thomas K. Harris1 and George J. Turner2 Department of Biochemistry and Molecular Biology‚ University of Miami School of Medicine‚ Miami‚ Florida 2 Department of Physiology and Biophysics and the Neurosciences Program‚ University of Miami School of Medicine‚ Miami‚ Florida 1 Summary
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1 Introduction 1.1 DEFINING POLYMERS Polymers are materials of very high molecular weight that are found to have multifarious applications in our modern society. They usually consist of several structural units bound together by covalent bonds [1‚2]. For example‚ polyethylene is a long-chain polymer and is represented by ÀCH2 CH2 CH2 À or ½ÀCH2 CH2 Àn ð1:1:1Þ where the structural (or repeat) unit is ÀCH2ÀCH2À and n represents the chain length of the polymer. Polymers are
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Introduction Americans have begun to eat more fast food because the way in which it is marketed; it’s cheap‚ convenient‚ finger-food‚ and it tastes good. Eating is one of the pleasures of life‚ although it can be bad for your health when eating fast foods‚ which are high in saturated fats‚ refined sugars‚ calories‚ and sodium that lead to obesity and diabetes. What are the effects of eating fast food and the impact it has on a person’s health? The Meaning of Fast Food Fast food is the term
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Final Biochemistry Exam Select the best answer for the following questions. 1. Which group of single-celled microorganisms has many members found growing in extreme environments? A) Bacteria B) Archaea C) Eukaryotes D) Heterotrophs E) None of the above 2. The three-dimensional structure of macromolecules is formed and maintained primarily through noncovalent interactions. Which one of the following is not considered a noncovalent interaction? A)
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2. Qualitative ORGANIC functional group tests in various homologous series | TEST FOR | TEST METHOD | OBSERVATIONS | TEST CHEMISTRY and comments | ALKENE or alkyne i.e. any non-aromatic unsaturated hydrocarbon with a double or triple carbon-carbon bond. | Bubble gas through‚ or add liquid to‚ a solution of bromine in hexane or water. | The orange/brown bromine rapidly decolourises‚ as a saturated colourless organic bromo-compound is formed. | R2C=CR2 + Br2 ==> BrR2C-CR2BrRCCR + 2Br2 ==> Br2RC-CRBr2R
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Reactions of pyridine Introduction: 1. Pyridine structure: 2. Iupac name: Pyridine‚ other name: Azine & Azabenzene. *Important commercial alkyl pyridinium compound is α - methyl- pyridine (2)‚ βpicoline (3)‚ γ- picoline ( 4 ) ‚ 2‚6 - lutidine ( 5 ) ‚ 3‚5 - dimethyl- pyridine ( 6 ) ethyl-2 - methyl- pyridine ( 7 ) and 2‚4‚6 - collidine ( 8 ) . In general‚ the alkyl -substituted pyridine as many other precursors used in pyridine E-commerce. From these further alkyl substituted pyridine
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