Adrenergic Agonists (a.k.a. Sympathomimetic Drugs) I. Direct stimulants of α and β receptors 1. Epinephrine (Adrenaline) 2. Norepinephrine (Levophed) 3. Levonordefrin (Neo-Cobefrin) 4. Dopamine (Intropin) 5. Ephedrine II. Direct stimulants of α receptors (α agonists) 1. Phenylephrine (Neo-synephrine) III. Direct stimulants of β receptors (β agonists) 1. Isoproterenol (Isuprel) 2. Selective stimulants of β2 receptors in the bronchi (for asthma) 2.a. Salbutanol (Ventolin) 2.b. Terbutaline
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Part 5: Synthesis‚ characterization and evaluation of COS-SMCC-(fatty acyl) CGKRK as in vitro gene delivery system to MDA-231 The delivery of siRNA is a great challenge due to its susceptibility to serum nuclease digestion‚ quick renal clearance. In addition to its anionic charge which hampers its cellular uptake. Therefore‚ the success of the gene carrier system relays on‚ the design of a delivery system that can protect siRNA molecules from enzymatic degradation‚ the ability to translocate the
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[pic] Scheme 1 Carboxylic acids can be converted to acid chlorides by treatment with a compound such as phosphorus trichloride (PCl3) or thionyl chloride (SOCl2).2 The reactive acid chloride can then be treated with a primary or secondary amine to
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4/27/11 SYNTHESIS AND CHEMILUMINESCENCE OF LUMINOL Abstract: Chemiluminescence occurs in nature and can be found in everyday products. For example‚ the light omitted by fireflies‚ deep sea fish and glow sticks is a result of this process. Luminol was synthesized from from 3-nitrophthalic acid and then combined with potassium ferricyanide and hydrogen peroxide to omit a blue light. The product of this reaction is very unstable and is made by losing a nitrogen and the electrons go from an excited
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11.1 Washing with cold distilled water Washing process is not only remove soluble protein‚ fat‚ and pro-oxidant‚ but may also remove antioxidant. Therefore the oxidative stability of muscle ultimately depends upon the antioxidant/prooxidant balance that remains after the muscle is washed. It suggests that washing may promote oxidation in mince since it effectively removes antioxidants from the fish. In addition‚ the neutral lipids are more easily removed than polar lipids‚ phospholipids and free
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Self-renewal and differentiation are fundamental stem cell fate decisions‚ which are essential for normal tissue development‚ homeostasis‚ and repair actin cytoskeleton and Rho-GTPases‚ mediate downstream signal transduction Serum response factor (SRF) and yes-associated protein (YAP) are two examples of mechano-sensitive transcription factors‚ which have recently been implicated in epidermal and mesenchymal stem cell differentiation Lab notes: Passive processes: transport driven by
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consist of pain‚ swelling‚ itching‚ redness‚ heat‚ and the loss of function. The response may consist of expansion of blood vessels as well as consequential leakage of fluid. This may certainly cause edema; a release of plasma proteases and vasoactive amines such as histamine. MRSA can be contracted in two different ways. Most of the time MRSA infections occur in individuals in a health care setting. Healthcare setting would consist of hospitals‚ nursing homes‚ and dialysis centers. MRSA is typically
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Naphthalimide derivatives are classified under intercalators‚ having a flat aromatic or heteroaromatic moiety and basic side chains. Amonafide is one of the most widely studied naphthalimides‚ which binds DNA by intercalation and also as Topoisomerase II inhibitors. The napthalimides showed excellent activity in breast cancer trials but failed in phase III trials due to its side effects and bone marrow toxicity [54]. The justly Naphtalene diimide (NDI) scaffold achieved recently as intercalators
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On average‚ crude oils are made of the following elements or compounds: * Carbon - 84% * Hydrogen - 14% * Sulphur - 1 to 3% (hydrogen sulfide‚ sulfides‚ disulfides‚ elemental sulfur) * Nitrogen - less than 1% (basic compounds with amine groups) * Oxygen - less than 1% (found in organic compounds such as carbon dioxide‚ phenols‚ ketones‚ carboxylic acids) * Metals - less than 1% (nickel‚ iron‚ vanadium‚ copper‚ arsenic) * Salts - less than 1% (sodium chloride‚ magnesium
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The National Survey on Drug Use and Health (NSDUH) indicates that 0.1% of 12-17-year-olds and 0.4% of 18-25-year-olds reported using methamphetamine in the past month‚ representing more than 150‚000 young users in the United States. Crystal meth is a common form of methamphetamine with a number of a street names‚ such as‚ ‘Tina’‚ ‘ice’‚ ‘crystal’ and ‘glass’. Crystal meth‚ or meth for short‚ can be taken by snorting it‚ smoking it or injecting it with a needle. Meth is a highly addictive stimulant
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