Drug Metabolism Prof. Patrick Davis Basic Medicinal Chemical Principles PHR 143M Fall-08 Importance of Drug Metabolism • The basic premise: Lipophilic Drugs --> Hydrophilic Metabolites (Not Excreted) (Excreted) • Water soluble => increased renal excretion -anddecreased tubular re-absorption of lipophilics. Importance of Drug Metabolism CH 3 CH 2OH CHO COOH OH O C 2H 5 Δ1-THC PC=6000 - O C O O HO OH COO OH OH Excreted Form O C 2H 5
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The formation of ASEAN was mainly driven by the desire to improve on diplomatic relations between Southeast Asian nations so that they could focus more on nation building efforts. The 1960s was the decade of tumult‚ where Southeast Asian nations faced various external tensions and conflicts from one another. During then‚ it was of utmost importance for SEA nations to improve multilateral diplomatic relations so as to promote peace in the region. This peace would refer to ensuring political stability
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Background information Polycystic kidney disease is an inherited kidney condition that causes cysts to grow on the kidneys. Commonly referred to as PKD‚ Polycystic kidney disease is present in two different forms‚ autosomal dominant and autosomal recessive. Autosomal dominant is much more common‚ and both variations cause about 5% of kidney failure in the world. There are two types of autosomal dominant PKD depending on the gene mutated. The two are usually defined by the age symptoms are present
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1a) 1b) Sedentary: < 45 ml/kg/min McArdle‚ W.D.‚ Katch‚ F. I.‚ & Katch‚ V. L. (2006) Untrained: 45 to 50 ml/kg/min McArdle‚ W.D.‚ Katch‚ F. I.‚ & Katch‚ V. L. (2006) Well-Trained: 50 to 60 ml/kg/min McArdle‚ W.D.‚ Katch‚ F. I.‚ & Katch‚ V. L. (2006) Highly Trained: 60-70 ml/kg/min McArdle‚ W.D.‚ Katch‚ F. I.‚ & Katch‚ V. L. (2006) Elite: > 70 ml/kg/min Lucia‚ A.‚ Hoyos‚ J.‚ Pérez‚M.
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Contents TWO ROLES OF THE HOLLY SPIRIT IN SPIRITUAL FORMATION 2 INTRODUCTION 2 DEFINITION OF SPIRITUAL FORMATION 3 THE ROLES OF THE HOLY SPIRIT IN SPIRITUAL FORMATION 3 EVALUATION AND CONCLUSION 5 REFERENCES 7 TWO ROLES OF THE HOLLY SPIRIT IN SPIRITUAL FORMATION I will not leave you comfortless; I will come to you. – John 14:18 INTRODUCTION In chapter 14 to 16 of the gospel of John‚ Jesus talks to his disciples about the promise of the Holy Spirit‚ who would come after Jesus
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Soil formation‚ or pedogenesis‚ is the combined effect of physical‚ chemical‚ biological and anthropogenic processes on soil parent material. Soil is said to be formed when organic matter has accumulated and colloids washed downward‚ leaving deposits of clay‚ humus‚ iron oxide‚ carbonate‚ and gypsum. As a result‚ horizons form in the soil profile. These constituents are moved (translocated) from one level to another by water and animal activity. The alteration and movement of materials within a soil
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Rong Gao Gao #1 Elizabeth Kim English 9 am - 10:30 am Date: July 12th‚ 2012 Summary of Racial Formation (By: Omi and Winant) In "Racial Formation". The author stated that Race is a racial formation. In 1982‚ a hypo-descent called Susie Guillory Phipps sued the Louisiana Bureau of Vital Records to change her racial classification from black to white. Unfortunately she lost‚ base on the 1970 state law‚ anyone with at least on-thirty-second "Negro blood" are consider black
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Anatomy of the Future Andreas Vesalius August 1‚ 1539 After attending college at the University of Louvain‚ I moved to Padua to study for my doctorate. After being offered the chair of surgery and anatomy‚ I pursued my desire to research the anatomy. Although surgery and anatomy are considered of little importance in comparison to other branches of medicine‚ I believe that surgery must be grounded in anatomy. I have been given the opportunity to perform my research on the cadavers of executed
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and society’s characteristics by which we are symbolized and recognised as to who we are. In this assignment I intend to explore the meaning of identity. In considering the link between personal and social‚ I will examine the process of identity formation‚ and discuss the extent in which we are able to control and shape our own identities. The definition of identity has been contested by many social scientists‚ as it has many influences‚ which has to be considered‚ such as‚ gender‚ social class
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BILIRUBIN FORMATION AND EXCRETION Bilirubin‚ the principal pigment in bile‚ is derived from the breakdown of hemoglobin when aged red blood cells are phagocytized by the reticuloendothelial system‚ primarily in the spleen‚ liver and bone marrow. About 80% of bilirubin formed daily comes from the degradation of hemoglobin. The remainder comes from destruction of heme-containing proteins and catabolism of heme. When hemoglobin is destroyed‚ the protein portion‚ globin is reused in the body. The
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