Homology Modeling of Dopamine D2 and D3 Receptors: Molecular Dynamics Refinement and Docking Evaluation Chiara Bianca Maria Platania‚ Salvatore Salomone‚ Gian Marco Leggio‚ Filippo Drago‚ Claudio Bucolo* Department of Clinical and Molecular Biomedicine‚ Section of Pharmacology and Biochemistry‚ Catania University‚ Catania‚ Italy Abstract Dopamine (DA) receptors‚ a class of G-protein coupled receptors (GPCRs)‚ have been targeted for drug development for the treatment of neurological‚ psychiatric
Premium
Loradatine : Claritin‚ Schering-Plough b. What is the mechanism of action. Like other H1-blockers‚ loratadine competes with free histamine for binding at H1-receptors in the GI tract‚ uterus‚ large blood vessels‚ and bronchial muscle. Claritin also has a weak affinity for acetylcholine and alpha-adrenergic receptors. c. What is the use of the medication. The specific conditions that are treated with it. Claritin is an antihistamine that relieves the sneezing‚ runny nose‚
Premium Blood Gastric acid Pharmacology
upgraded back to Class B since 2009 in the UK. The most important psychoactive substance in the cannabis plant is delta-9-tetrahydrocannibinol (THC)‚ which is a chemical compound found in the cannabis plant that binds to specific receptors in the brain called cannabinoid receptors. In low doses‚ THC can cause some pain reduction‚ may reduce aggression‚ can stimulate appetite‚ and may help reduce nausea. Higher doses may cause a ’high’ leading to altered perception of time and space‚ and feelings of happiness
Premium Memory Cannabis Cognition
Anti- NMDA Receptor Encephalitis What encephalitis is? Encephalitis is characterized to be an inflammation of the brain‚ which is often due to infection. Not contagious Not hereditary What this type of encephalitis is? Anti-NMDA receptor encephalitis is a disease where antibodies produced by the body’s own immune system attack the NMDA receptors in the brain. What NMDA receptors are? NMDA receptors are electrical impulse controllers in the brain. Their function result in all autonomic
Premium Immune system Antibody Psychology
beyond our consciousness. Receptors responsible for perception of stimuli are found in many places: skin‚ eyes‚ ears‚ mouth‚ blood vessels‚ lungs‚ brain—frankly‚ every cell in the body has sensory receptors. These receptors are broadly classified as photoreceptors (sensitive to light)‚ chemoreceptors (sensitive to chemicals)‚ thermoreceptors (sensitive to warm or cold)‚ mechanoreceptors (sensitive to stretch/pressure)‚ and nociceptors (sensitive to damage). Sensory receptors are found on neurons
Premium Eye Sensory system Visual acuity
Question #5 Unlike their friend Jemima‚ the other patients have all experienced a drop in blood pressure (Hypotension) and have an elevated heart rate (125-135 bpm) Hypertension occurs when blood pressure drops below 90 mm Hg systolic or 60 mm Hg diastolic number. Due to the girls all consuming substances that affect their bodies to normally retain water‚ they have all suffered similar symptoms but to different degrees. Dehydration causes the volume of blood circulating through the body to decrease
Premium Kidney Blood pressure Blood
Enkephalins and Endorphins Do you have an experience that you cut your finger‚ it is painful in the few minutes‚ after that‚ it stops that feeling. Do you know why? This related a kind of hormone called opioid peptides. Their function is as j nanalgesic hormones. Opioid neuropeptides were first discovered in 1974 by two independent groups of investigators: John Hughes and Hans Kosterlitz of Scotland isolated — from the brain of a pig，called enkephalins.1 Around the same time‚ in a calf brain‚
Premium Nervous system Opioid Hypothalamus
for it‚ right? Marijuana is a medical option for anyone who has cannabinoid receptors in their brain. Who has cannabinoid receptors in their brain? Good question; The truth is‚ we all do. Inside all of our brains are receptors that make it possible to successfully receive and process marijuana. These receptors are conveniently located in the basal ganglia‚ the hippocampus‚ and the cerebellum. The locations of these receptors are interesting because they are located in the parts of the brain that are
Premium Cannabis Brain Medicine
phytoestrogen produces can depend on the dose of the phytoestrogen. The phytoestrogen can act like estrogen at low doses but block estrogen at high doses (Phytoestrogens and breast‚" 2001). Estrogen activates a family of proteins called estrogen receptors. There are many positive benefits with a phytoestrogen-rich diet‚ especially one rich in legumes‚ fruit and other fibers ("Phytoestrogens: pros and‚" 2000). With the negatives‚ doctors are concerned that women who have had hormonally dependent
Premium Menopause Breast cancer Cancer
Jones‚ M (2002)‚ Social Work Research: Ethical and Political Contexts‚ London: SAGE Publications. DeLong MR (1990)‚ Primate Models of Movement Disorder of Basal Ganglia Origin‚ Trends Neurosci‚ Vol.13‚ No.7‚ p.281-5 Demirdamar. R (1998)‚ Dopamine Receptor Subtypes: From Basic Science to Clinical Application‚ Netherlands: IOS Press Dr Fitzpatrick. J‚ & Wallace. M (2006)‚ Encyclopedia of Nursing Research‚ Second Edition‚ New York: Springer Publishing Company‚ Inc. Freberg. L (2006)‚ Discovering
Premium Parkinson's disease Dopamine Neurotransmitter