GDF15/MIC-1 is a product of macrophage activation‚ suggesting that it may be involved in chronic inflammatory processes (-). GDF15 is a stress-responsive member of the TGF-β superfamily and initially described as macrophage inhibitory cytokine (-). Although GDF15 has been described in many solid tumors for almost 10 years‚ the nature of its receptor is still unknown. There is some evidence of Smad signaling pathway activation‚ suggesting GDF15 may act through TGF-β receptor superfamily pathways (-)
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Wal-Mart’s Music Censorship Imagine Green Day just came up with a great album that everyone has been raving about. The excited fans decide to head over to the local Wal-Mart to grab an easily accessible copy of this album. Sadly‚ they find that Wal-Mart will not sell the album because Green Day refuses to self-censor their songs‚ which Wal-Mart demands of all artists. Wal-Mart also refuses to stock CDs with parental advisory stickers on them‚ although it should be the consumer’s choice on whether
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April Jean Delos Santos BBF 2-9s 1. What is the significance of studying the different worlds as experienced by poets‚ dramatist‚ essayist‚ storytellers‚ playwrights‚ and writers? Studying Literature can be an eye-opening experience. Reading some great works of World Literature helps us understand things even ourselves. Because by reading we are exposing ourselves to new ideas‚ we begin to have better judgment on things and we benefit from other’s point
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Introduction The purpose of this lab is to synthesize Lidocaine from 2‚6-dimethylaniline‚ using diethyl amine‚ 2-chloroacetyl chloride‚ acetic acid‚ and toluene. The Lidocaine was made by adding 2‚6-dimethylaniline to 2-chloroacetyl chloride in acetic acid. Sodium acetate is added in order to make the compound soluble. The product is dried‚ then treated with diethyl amine and toluene. This is refluxed using a water-cooled reflux condenser. The vapor is condensed by the cold water as the compound
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u03a2 Product Analysis Vyvanse (lisdexamfetamine dimesylate) by Shire INC US Vyvanse (lisdexamfetamine dimesylate) is a schedule II narcotic medication prescribed in the United States for Attention Deficit Hyperactive Disorder (ADHD). Currently it is patented by the pharmaceutical giant Shire Inc. US‚ and the drug is in phase 3 trials for approval to treat binge eating. (Pipeline‚ n.d.) There have been rumors the drug is in trials to treat a range of diseases from schizophrenia‚ narcolepsy
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EXTRACTION Organic Chemistry Laboratory This experiment was conducted in order to compare single and multiple extraction of caffeine from dried tea leaves and to calculate the percentage yield of caffeine for both extraction procedures. The group was assigned to do the multiple extraction. Before the extraction proper‚ the water bath containing the anhydrous sodium carbonate and distilled water was heated. As the sodium carbonate dissolves‚ tea leaves were added in the mixture and allowed to
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The average person is faced with thousands of issues every single day‚ and often they are recognized and handled‚ but other times there are some that are overlooked. Sleep debt‚ an issue that many do not even know exist‚ and yet are plagued by on it an everyday basis. When you skip a night of full rest‚ is it possible to catch up? Most people will simply attempt to return to a normal schedule‚ but yet they cannot shake the feeling of lethargy. This issue is the subject of many studies and investigations
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Loggerheads also modify habitats as a result of their foraging activities. The fragments of hard-shelled organisms that loggerheads consume are either discarded or ingested and later deposited with feces at a different location. By reducing the particle size of the shells‚ loggerhead turtles contribute to nutrient recycling in benthic ecosystems by increasing the rate of shell disintegration. Additionally‚ a foraging behavior called infaunal mining has a significant effect on substrate characteristics
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In the most simple form‚ FM digital synthesis consists of two sine waves. One is called the modulating wave and the other is called the carrier wave. The carrier wave is the only waveform that is audible. The modulating wave does just as it sounds‚ it modulates the amplitude of the carrier wave‚ and acts as a control value. The frequency of the modulating frequency controls the rate of change in the carrier wave; it controls how fast the modulation occurs in the carrier wave. And the amplitude of
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signals on the membrane of a single neuron • Graded potentials decay with distance (electrotonic conduction); longdistance transmission depend on transforming signals to APs • Typically‚ alternating electric (within neuron) and chemical signals (between neurons) • Postsynaptic potential affected by number and frequency of APs Passive spread of electric signal Sub-threshold current flowing along the membrane decays with distance: • Resistance of cytoplasm • Leakage of charge across the membrane
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