proteasome in vivo did not immediately alter the normal life cycle of the cell [10]. The ensuing studies revealed that the proteasome was important in the activation of NF-κB [11] implicated as one of the mechanisms of tumor cell resistance to apoptosis. Based on these observations‚ in August 1994‚ Julian Adams examined bortezomib as a possible anti-cancer molecular targeting agent. By 1997‚ it was also shown that bortezomib could have potential influence on inhibiting tumor growth and metastasis
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treatment. Other hydroxycinnamic acids and derivates such as caffeic acid phenyl ester‚ ferulic acid‚ p-coumaric acid and caffeoylquinic acids have showed anticarcinogenic activities against HT-29‚ CaCo-2‚ SW480‚ HCT116 involving cell cycle arrest and apoptosis (Huang and others 1986; Jacnike and others 2011; Puangpraphant and others 2011; Wang and others
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“That role is so powerful that cells co-evolved an emergency death pathway to keep c-Myc expression in check. If c-Myc’s production spins out of control in an otherwise normal cell‚ the cell immediately commits suicide through a process called apoptosis. But in cancer cells in which c-Myc is overproduced‚ this suicide pathway is compromised‚ allowing the cell to survive and proliferate (Young).” It is a very strong Proto-oncogene that can mutate into an oncogene that can cause cancer and tumors
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Cancer Institute at Cedars-Sinai Medical Center‚ pepper component caused human prostate cancer cells to unde4rgo programmed cell death or apoptosis. When an experiment was preformed amongst a few mice‚ the result where evident. Caspsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecule pathways leading to apoptosis. Prostate cancer tumors treated with caspsaicin were about one-fifth the size of tumors in non-related mice.
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3. Summarize an article from a peer reviewed journal dealing with one of the topics presented in the article. The article reviewed discussed the topic of human cytotoxicity in response to exposure to glyphosate‚ its major metabolite (AMPA)‚ and the commonly added surfactant compounds found in major herbicides. Glyphosate exposure has increased world-wide at an exponential rate along with the production of genetically modified crops. Currently up to 75% of genetically modified crops are treated
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Susan Chong DSR 610 6 May 2015 EZH2 and Notch1 signaling in glioblastomas and breast cancer stem cells Within a tumor exists a subpopulation of cells that present less abnormal characteristics; however‚ there exists another type that hold the potential to recreate and expand tumor mass. The latter share similar characteristics to normal stem cells‚ which are the unlimited ability to self-renew and the ability to maintain undifferentiated. Over the course of time‚ these cells will differentiate into
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Chapter 33 notes: Intrinsic cellular defense against virus infection 1. Toll- like receptors sense virus infections a. Toll-like receptors (TRL) i. Located on the cell surface or in endosomal membranes = recognize conserved structures found in pathogens ii. Highly conserved receptors from flies humans iii. Most mammals have between 10-15 (humans = 10) iv. TLR – 2: lipoproteins/glycoproteins (mealsels‚ hepB‚ herpes) v. TLR– 3: dsRNA (west
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Bibliography: • Fauci‚ A. et. al. (2005) Harrison ’s Principle of Internal Medicine‚ 17th edition. New York: McGraw-Hill Companies‚ Inc. • Hughes‚ David ‚ and Huseyin Mehmet. (2003) Cell Proliferation and Apoptosis. New York: Garland Science. • Medina‚ L.V. et al. (2010) Philippine Cancer Facts and Estimates. Manila: Philippine Cancer Society. • Pizzorno‚ J. E.‚ & Murray‚ M. (2005).Textbook of Natural Medicine e-dition: Text with Continually Updated Online
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Johnson Syndrome is an inmune disease charactherized by a detachment of the epidermis from dermis. It could be fatal and the pathophysilogy involves a complex hypersensitivity reaction with the participation of T lymphocytes that induce keratinocyte’s apoptosis. The syndrome can be cause by drigs‚ infections and malignancies. The diagnosis is difficlut due to the abscense of specific manifestations and laboratory tests. There is a genetic predisposition in individuals with certain HLA types. The disease
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1. Rosalind Franklin’s discovered that DNA contains nitrogenous bases the principle of base pairing the X-ray diffraction pattern of DNA‚ which helped uncover its double helix structure how to sequence DNA molecules the bonding energy of DNA molecules 2. Which of the following carries amino acids to ribosomes‚ where amino acids are linked into the primary structure of a polypeptide? mRNA tRNA hnRNA rRNA all of these 3. The nitrogenous base
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