2.3. Method Development 2.3.1. Preparation of Stock Solution 100 mg of the synthesized compound was made up to 100 ml into a 100ml standard flask with ethanol to give a solution of 1000 μg/ml. 2.3.2. Determination of λ max 1 ml of stock solution was pipetted out was made up to 10 ml into a 10ml standard flask with ethanol to obtain strength 100 μg/ml and scanned at 200-400nm using a UV spectrophotome-ter (Deepak V Bageshwar et al.‚ 2010). 2.3.3. Preparation of Standard Calibration Curve Aliquots
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In the reaction mechanism‚ a carboxylic acid‚ m-toluic acid is used to synthesize N‚N-diethyl-m-toluamide‚ also know as DEET‚ through a nucleophilic acyl substitution reaction. The reaction begins by first converting the m-toluic carboxylic acid into an acyl chlorosulfite through a reaction using thionyl chloride. The carboxylic acid is converted into an acyl chloride because the acyl chloride is more reactive. In this step‚ hydrochloric acid is formed from a hydrogen on the carboxylic acid and a
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nanoparticles have unique properties which help in molecular diagnostics‚ in therapies‚ as well as in devices that are used in several medical procedures. The major methods used for silver nanoparticle synthesis are the physical and chemical methods. The problem with the chemical and physical methods is that the synthesis is expensive and can also have toxic substances absorbed onto them. To overcome this‚ the biological method provides a feasible alternative. The major biological systems involved in this are
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Acetylsalicylic acid is the active pharmaceutical ingredient in aspirin and can be synthesized by the esterification reaction of salicylic acid and acetic anhydride in the presence of an acid catalyst. An esterification reaction is when an acid is converted into an ester by combining with an alcohol and removing a water molecule. When heating the salicylic acid mixture in the warm water bath‚ the mixture should be removed from the bath within 8 minutes‚ to reduce the chance of the acetylsalicylic
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Unit 4 Assessment 2-Benzoic Acid Synthesis Synthesis and Investigation of Benzoic Acid Our aims: Create benzoic acid using benzaldehyde and hydrogen peroxide. Then remove some impurities from the benzoic acid crystals. Apparatus: Titration Pipette (25 cm3) Burette (50 cm3) Retort stand Clamp Conical flask (250 cm3) Volumetric flask (250 cm3) and stopper White tile Beakers (250 cm3) Dropping pipette Filter funnel Deionised water Phenolphthalein indicator Volumetric flask
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Figure 6: Imatinib The first imatinib drug synthesis was done by Zimmermann (figure 7) in 1993‚ he used a chain of the reaction to reach to imatinib but the important part is that both guanidinium nitrate 7 and aminopyrimidine 8 are precipitated from the respective reaction mixtures by the addition of Figure 7: imatinib synthesis by Zimmermann insolubilizing solvents‚ so we got a condensation reaction between guanidinium salt 7 with enone “9” to form the aminopyrimidine “8” then “8” is
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CHEM%2315%Fall%2014% Creating useful and beautiful molecules using synthetic organic chemistry – Synthesis of Aspirin and Indigo INTRODUCTION Aspirin Salicylic acid occurs naturally in the bark of willow trees. Prior to the 1800’s‚ willow bark was often brewed into a tea‚ or chewed to relieve pain. While the salicylic acid is effective at reducing pain it was found to irritate the lining of the stomach. It was mostly by chance that on August 10‚ 1897 Felix Hoffmann‚ a German chemist who obtained
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crystals 18.287g Claim: Based on my calculations‚ the theoretical yield of Aluminum was 18.160g‚ and the actual yield was 18.287g. This gives a percent yield of 100.699%. Evidence/ Reasoning: By looking at the overall reaction involved in the lab‚ we can see that two moles of Aluminum are needed to react in the reaction‚ producing 2 moles of KAl(SO4)2 ·12H2O. This lets us know that however many moles of Aluminum there are in the original sample will be equal to
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In “Helping Students Use Textual Sources Persuasively‚” Margaret Kantz talks about how individuals should read texts to write a synthesis essay. To write a synthesis essay‚ one should be able to come up with an argument and find information from other sources‚ and use them as proofs to back up the argument. First‚ Kantz talks about the mistakes that students usually make when they write this essay. For instance‚ Shirley made a mistake by reading a repeating and telling the story instead of creating
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report discussing the purity of my aspirin sample I produced. When I carried out the experiment to produce an aspirin sample I had to take a few results I had gained from carrying out the experiment later used these to work out the experimental error and percentage % yield. The results I used where the published value of what temperature pure aspirin melts at‚ the temperature my aspirin sample melted at‚ the weight of pure aspirin and the weight of impure aspirin. Firstly I worked out the experimental
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