Synthesis of Aspirin and Oil of Wintergreen Janelle Alyssa P. Prudente De La Salle University-Dasmariñas Dasmariñas City‚ Cavite‚ Philippines ABSTRACT In this experiment‚ acetylsalicylic acid commonly known as aspirin and methyl salicylate‚ commonly known as oil of wintergreen‚ was synthesized from salicylic acid. This study will show that it is possible to show two very different organic compounds from the same common starting material. For the synthesis of aspirin‚ salicylic acid
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Symone E. MoxeyLab Partner: Lynden Cooper Synthesis of Aspirin (Acetylsalicylic Acid) Abstract:- Aspirin (acetylsalicylic acid) is produced experimentally in the lab. The resulting percentage yield is 65.5%. The purity of the obtained product is tested using the melting point and Ferric Chloride Test (FCT). The aspirin was massed‚ and the melting point was determined. Based on the data collected‚ there was a total yield of 1.757g of purified aspirin‚ which had a melting point range of 125°C-130°C
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INTRODUCTION 3 2.1 The background information of Aspirin 3 2.11 History 3 2.12 chemical structures 4 2.2 The background information of Acetaminophen 5 2.21 History 5 2.22 Chemical Structures 6 3.0 BODY 6 3.1 Synthesis 6 3.11 Synthesis of Aspirin 6 3.12 Synthesis of Acetaminophen 7 3.2 Mechanism of Action in Human Body 9 3.2.1 Pain as a warning system 9 3.2.2 Aspirin 9 3.2.3 Acetaminophen 10 3.3 Side effects 10 3.3.1 Side effects of Aspirin 10 3.3.2 Side effects of Acetaminophen 11 4
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Nowadays‚ aspirin is often given to patients immediately after a heart attack to prevent recurrence or cardiac tissue death. Aspirin is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are medications with analgesic‚ antipyretic (something that reduces a fever)‚ and in higher doses anti-inflammatory effects. Non-steroidal
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acetylsalicylic acid through the organic synthesis from the reaction of salicylic acid to acetic anhydride‚ the starting materials. Instead of using acetic acid‚ acetic anhydride was used as solvent since the anhydride reacting with water to form acetic acid tends to drive the reaction to the right. It results from the elimination of a molecule of water from two molecules of acetic acid (see Fig. 11.2). Figure 11.3 below shows the balanced chemical reaction of the synthesis of acetylsalicylic acid.
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Date Experiment conducted: 05/02/2009 Date Report Written: 08/02/2009 Synthesis of Acetyl salicylic acid (Aspirin) Abstract Introduction: The following report contains information on how to produce aspirin. The experiment has been carried out on a small laboratory scale. The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride. The synthesis of aspirin is classified as an esterification reaction. This is a substitution reaction where the alcohol group
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Contents 1.0 Abstract Acetaminophen and aspirin are both well-known drugs that relieve pain and reduce fever. This report looks at acetaminophen as a potential substitute for a patient who is allergic to aspirin. Acetaminophen‚ a common analgesic drug that can be bought over the counter‚ was synthesised by Hormon Northrop Morse. With acetaminophen consisting of a benzene ring‚ an amide and an alcohol group‚ it has the ability to stop pain and reduce fevers. However‚ due to the state of technology
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BMS3021 – Research Topic: Aspirin TOPIC SUMMARY Aspirin is able to inhibit the synthesis of the Thromboxane A2 precursor‚ by irreversibly binding to the COX-1 enzyme Lack of Thromboxane A2 means that there is no signalling for platelet aggregation so there is no blood clot formation‚ leading to its ability to act as a ‘blood thinner‘ SALT found that in a low-dose of 75mg of Aspirin a day‚ secondary prophylaxis of new cardiovascular events were reduced by 16-20% By decreasing the daily dose to 75mg
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prevents bodily harm and intends to cure an illness Effectiveness of a drug measured by trial and error WM2/WM3– Medicines from nature Medicines from willow bark – willow bark contain an active ingredient know as salicylic acid which used to make aspirin (pain reliever) Identifying salicylic acid Three chemical tests which are used to predict the structure of salicylic acid 1. Salicylic acid in aqueous solution is weakly acidic ( presence of COOH group) 2. Salicylic acid reacts with alcohols
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Synthesis of Aspirin from Oil of Wintergreen Objectives: In this experiment‚ the Oil of Wintergreen is put into an Erlenmeyer flask containing sodium hydroxide to create sodium salicylate. The solution is then refluxed which means that the solution will be boiled in a base‚ then condensed in a condenser. This replaces the carbon on the ester at carbon 1‚ with an oxygen atom which will have an ionic bond with a sodium anion. This yields sodium salicylate which will be acidified in methanol
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