Fred and Theresa Holtzclaw Chapter 7: Membrane Structure and Function Name_______________________Period___________ Chapter 7: Membrane Structure and Function Concept 7.1 Cellular membranes are fluid mosaics of lipids and proteins 1. The large molecules of all living things fall into just four main classes. Name them. 2. Explain what is meant when we say a molecule is amphipathic. 3. In the 1960s‚ the Davson-Danielli model of membrane structure was widely accepted. Describe
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solutes move through the 20 MWCO membrane? Why or Why not? 2. Did Na+Cl- move through the 50 MWCO membrane? Activity 2: 1. Are the solutes moving with or against their concentration gradient in facilitated diffusion? 2. What happened to the rate of facilitated diffusion when the number of carrier proteins was increased? 3. In the simulation you added Na+Cl- to test its effect on glucose diffusion. Explain why there was no effect. Activity 3: 1. Which membrane resulted in the greatest pressure
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Nephritic syndrome ("nephritis") Indicates acute inflammation of glomeruli hematuria (including red cell casts) mild to moderate proteinuria oliguria‚ hypertension and mild edema 2.Nephrotic syndrome Indicates excessive permeability of the filtration membrane to plasma proteins. Clinical manifestations of renal diseases (contd..) heavy proteinuria (adult more than 3.5 gm/day) hypoalbuminemia (less than 3.0 gm/dL) severe generalized edema Hyperlipidemia and lipiduria
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semi‐permeable membrane (dialysis tubing) and sucrose will create an osmotic environment similar to that of a cell. Using different concentrations of sucrose (which is unable to cross the membrane) will allow us to examine the net movement of water across the membrane. INTRODUCTION A major determinant of diffusion in a biological system is membrane permeability. Small‚ uncharged molecules pass through cellular membranes easily‚ while most and/or charged molecules cannot pass through the membrane. The
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mitochondrial dysfunction by the opening of the mitochondrial permeability transition pore (MPTP) that cause of irreversible damage. During reperfusion‚ oxygen and supplements are accessible for ischemic cardiomyocytes‚ so‚ intracellular acidosis washes out; however‚ calcium overload and dysfunction of contractile protein stimulation thanks to hypo contractility and sarcolemmal rupturing. MPTP is a nonspecific channel in the mitochondrial inner membrane and allows to the molecules smaller than 1.5 kDa to pass
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concentration of Na+ f ; there is a greater concentration of K+ e . When the stimulus is delivered‚ the ermeability of the membrane at that point is changed; and c ‚ initiating the depolarization of the membrane. Almost as soon as the depolarization wave has begun‚ a repolarization wave follows it across the membrane. This occurs as b . Repolarization restores the h of the resting cell membrane. The g is (are) reestablished by i . 2. 1 5 3 2 4 5. Electrical Chemical 6. a) latent phase‚ ~3 msec‚ the
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REVIEW SHEET EXERCISE 1 Cell Transport Mechanisms and Permeability Simple Diffusion The following refer to Activity 1: Simulating Dialysis (Simple Diffusion). Which solute(s) were able to pass through the 20 MWCO membrane? NONE 1. According to your results‚ which solute had the highest molecular weight? Albumin 2. Which solute displayed the highest rate of diffusion through the 200 MWCO membrane? Na+Cl 3. Using the data from Chart 1‚ explain the relationship between the
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TYPE 1: IMMEDIATE TYPE 2: ANTIBODY MEDIATED Feature Known as anaphylactic HS Fast response (minutes) Disorders/ Reactions Athopy Clinical manifestation includes asthma‚ eczema‚ hay fever‚ food allergy Has family history with similar condition Show immediate wheal and flare skin reaction to allergen Strong hereditary linkage seen in human Autoimmune haemolytic anaemia Spontaneous/ induced by drugs Reacts to blood group Ag – produce Ab to self RBC Test: direct antiglobulin test
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diffuse freely in a cell. Other molecules need assistance through the cell membrane through a process called facilitated diffusion. Osmosis moves from an area of low concentration to high concentration. In osmosis water moves in the opposite way. Water flow is determined by the concentration‚ not the nature of the solute. There are a couple of things to consider for diffusion to work. The size of the cell‚ permeability‚ molecules in the cell‚ and time it takes to diffuse. Processed bits of food
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glycocalyx may change almost continuously‚ allowing it to keep ahead of immune system recognition mechanisms and avoid destruction. (Cancer is discussed on pp. 145-146) 3.2 Selective permeability is a characteristics of healthy‚ intact cells. When a cell (or its plasma membrane) is severely damaged‚ the membrane becomes permeable to virtually everything‚ and substances flow into and out of the cell freely. This phenomenon is evident when someone has been severely burned. Precious fluids‚ proteins
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