Synthesis of Aspirin Ling Tecson Gamido‚ Mitchiko Mariel M. Mizukami Abstract Acetylsalicylic acid‚ or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride‚ both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order
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EXERCISE 11 Synthesis of Aspirin (Acetylsalicylic Acid from Salicylic Acid) RAQUID‚ Rency J Group 5 18L I. Introduction Due to the demand of certain reagents in the laboratory in order to perform and conduct further experiments or produce essential compounds‚ chemists continuously develop organic synthesis. This process aims to prepare and synthesize desired organic compounds from commercially or readily available ones by providing the simplest route in synthesizing the compound
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Unit 4 Assessment 2-Benzoic Acid Synthesis Synthesis and Investigation of Benzoic Acid Our aims: Create benzoic acid using benzaldehyde and hydrogen peroxide. Then remove some impurities from the benzoic acid crystals. Apparatus: Titration Pipette (25 cm3) Burette (50 cm3) Retort stand Clamp Conical flask (250 cm3) Volumetric flask (250 cm3) and stopper White tile Beakers (250 cm3) Dropping pipette Filter funnel Deionised water Phenolphthalein indicator Volumetric flask
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Acetylsalicylic acid is the active pharmaceutical ingredient in aspirin and can be synthesized by the esterification reaction of salicylic acid and acetic anhydride in the presence of an acid catalyst. An esterification reaction is when an acid is converted into an ester by combining with an alcohol and removing a water molecule. When heating the salicylic acid mixture in the warm water bath‚ the mixture should be removed from the bath within 8 minutes‚ to reduce the chance of the acetylsalicylic acid decomposing
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Hydrocinnamic acid underwent bromination using N-bromosuccinimide and AIBN. As one lab partner set up the reflux apparatus‚ the other measured the chemicals used in the lab experiment. 2.10 g of hydrocinnamic acid was used. It was observed as white and had a slight cinnamon smell. The amount of NBS was 2.49g and was measured in the fume hood. AIBN was measured at .030 g. 10 mL of acetic acid was also obtained. The reflux apparatus consisted of a 25 mL flask with a stir bar in a water bath. The chemicals
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This solution served as the source of ionic Iron for the remainder of the lab and was labeled “stock ionic Iron solution.” Next‚ a 50-mL aqueous ionic Iron and FerroZine® complex solution was prepared by adding 5.00mL stock ionic Iron‚ 3-mL of acetic acid buffer‚ 2-mL of 5% hydroxylamine hydrochloride‚ allowing five minutes for hydroxylamine to reduce Fe3+ to Fe2+‚ adding 2.5-mL of 0.01 M FerroZine® solution‚ and mixing well. A single beam Agilent technologies CARY60-UV-Vis Spectrophotometer was then
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which both prove the erythro-2‚3-dibromo-3-phenylpropanoic. Determination of the Stereochemistry of 2‚3-dibromo-3-phenylpropanoic acid. Introduction The purpose of this experiment was to determine the mechanism of the reaction of trans-cinnamic acid with the addition of bromines to 2‚3-dibromo-3-phenylpropanoic acid. An addition of bromine was added to trans-cinnamic acid and it is necessary to determine whether the intermediates were syn or anti addition or a mixture of them both to find the stereochemistry
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Small samples of acetaminophen‚ acetylsalicylic acid‚ cellulose‚ starch‚ and caffeine were obtained. These samples were then placed into seperate sets of test tubes that contained water‚ acetone‚ or dichloroethane. Solubilities were then tested for each sample in each solution which can be seen in Table 5. Next‚ four random pills were obtained and weights were taken of each. Each of the pills were grinded up using a separate mortar and pestle. The grinded up pills were then weighed. The grinded
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De-esterification for Synthesis of Benzoic Acid BATCH REACTOR Shane Bulk Chris Crosley David McGuire Max Skula Yunjing Song Shriram Sundarraj Nelson Zhou 155:416 Process Laboratory II Professor Jerry Sheinbeim January 28 – February 28‚ 2014 ABSTRACT The observed reaction that took place in this experiment was the de-esterification of ethyl benzoate to form benzoic acid. This experiment was used to determine the rate constant k of the synthesis of benzoic acid at different temperatures
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Synthesis of Salicylic Acid from Wintergreen Oil Objective – Preparation of salicylic acid (organic synthesis) from methyl salicylate utilizing previously used procedure from the nineteenth century. The final product will then be evaluated in comparison to salicylic acid made from benzene. Discussion – In this synthesis‚ methyl salicylate is the starting material or precursor and salicylic acid is the target product. It is the major constituent of wintergreen oil. The difference in structures
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