Benzocaine is a topical anesthetic commonly used to relieve pain or discomfort . There are many brands of benzocaine and it is the active ingredient in various over-the-counter analgesic ointments . Benzocaine is the ethyl ester of paraaminobenzoic acid and as an ester it can be classified by Fischer esterification. Fischer esterification reactions typically include a carboxylic acid and alcohol as well as a dehydrating agent . Since esterification reactions are slow‚ a catalyst is required. The
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The obtained mass of benzocaine and benzoic acid mixture was measured to be 2.075 grams. Following being dried for a week the mass of benzocaine was recorded to be 0.250 grams‚ and benzoic acid was recorded to be 0.600 grams. The melting point range of benzocaine was measured to be 89.5°C-91.5°C‚ while benzoic acid’s melting point range was measured to be 129°C-131.3°C. The percent mass recovered was calculated to be 40.96% for the experiment. Table 1 illustrates the collected information. Starting
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Experiment # 45: Benzocaine Abstract The local anesthetic‚ benzocaine‚ was synthesized via the esterification of p-aminobenzoic acid with ethanol. The percent yield of crude product was determined to be 21% and the melting point was recorded at 86.2°C ± 0.2°C‚ with a 6.3% error from 92°C‚ the literature melting point of pure benzocaine. The crude product was then recrystallized to improve the purity of benzocaine and 57.4% was recovered. The new melting point range was measured at 89.1°C ±
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Background: Benzocaine | | C9H11NO2 | Reaction scheme for Fischer Esterification of p-aminobenzoic acid: Synthesis of Benzocaine.3 In 1890‚ a chemist named Ritsert‚ was the first to synthesis benzocaine and introduced it in the market in 1902. Benzocaine is a pain reliever and has many active over-the-counter ingredients. It is also used as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharynegeal and tracheal reflexesl.2 Sodium
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|Student Number |101 | | | | |Student Name |Sunil_3 Patel | | |
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Figure 1: Formation of benzocaine from p-aminobenzoic acid Experimental P-aminobenzoic acid (1.211g) and absolute ethanol (15mls) were combined with three boiling chips in a 50ml round bottom flask. The round bottom flask was placed on a heating plate and was refluxed starting at 109 ̊C. The solution began boiling at 111 ̊C. It was allowed to reflux for approximately 30 minutes and the solid was dissolved. The round bottom flask was then placed in an ice bath and allowed to cool to
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indeed benzocaine; this conclusion stems from the fact that stock benzocaine has been described as having a white/colorless tint‚ as well as being ododrless2‚ characteristics that are shared with the product of this procedure. It is also unlikely that an influx of base would have caused an unknown product to form‚ due to the weak nature of sodium bicarbonate‚ which would alter the equilibrium more than the reaction itself. Therefore‚ although the procedure did not produce as much benzocaine as expected
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unknown containing either an acid and a neutral compound or a base and a neutral compound‚ but since the components are unknown‚ the student conducts the experiment as if all 3 compounds are present. In this particular experiment‚ the compounds are benzocaine‚ salicylic acid‚ and naphthalene. An appropriate organic solvent is used to create the ether phase. Diethyl ether is used because it has low solubility in water but will dissolve the components of the mixture (creating liquid layers)‚ is not acidic
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groups‚ and combine your three samples of benzoic acid‚ (separately!) combine your three samples of benzocaine‚ and combine your three samples of fluorenone. (If you misread this and mix everything together‚ no worries‚ you can just repeat the extraction to separate them again.) Now‚ one group is going to recrystallize the benzoic acid from water‚ one group is going to recrystallize the benzocaine from ethanol and water‚ and one group is going to recrystallize the fluorenone from
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Otitis is a general term for inflammation or infection of the ear‚ in both humans and other animals. It is subdivided into the following: Otitis externa‚ external otitis‚ or "swimmer’s ear" involves the outer ear and ear canal. In external otitis‚ the ear hurts when touched or pulled. Otitis media or middle ear infection involves the middle ear. In otitis media‚ the ear is infected or clogged with fluid behind the ear drum‚ in the normally air-filled middle-ear space. This very common childhood
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